Ongoing economic evaluation is a central function for any system that must operate with limited, finite resources, that is, all mobile creatures. The need for neural valuation mechanisms arises from the sheer breadth and variety of information available to a mobile creature's nervous system, and the fact that sensory stimuli and possible behavioral output must be prioritized. This presents a fundamental information-processing problem: vastly different stimuli and behavioral output must be placed on some common valuation scale. Without internal valuation systems in the nervous system, a creature would be unable to assess the relative value of intrinsically different events like drinking water, smelling food, scanning for predators, sitting quietly in the sun, and so forth. To decide on an appropriate behavior, the nervous system must estimate the value of each of these potential actions or stimuli, convert it to a common scale (currency), and use this scale to determine a course of action. This issue has long been appreciated by behavioral psychologists and economists; however, only recently have the underlying neural substrates been addressed experimentally in humans. Midbrain dopamine systems and the target neural structures to which they project have now been identified as participating in the valuation of future rewarding events. In particular, computational work has shown that a subset of these dopamine neurons encode and distribute a prediction error signal representing the ongoing difference between actual reward and predicted reward. This prediction error model of dopaminergic function has now led to behavioral models that predict human behavior on sequential decision-making tasks. These tasks ask the question: """"""""How do humans value ongoing changes in rewarding stimuli?"""""""", a question with important implications for drug abuse. However, there has been no biological measure to correlate with these model-based behavioral predictions. The long-term goal of this proposal is to use functional magnetic resonance imaging (fMRI) during the execution of sequential decision tasks to probe the brain responses that correlate with human performance. This work will provide fundamental insights into valuations mechanisms present in human brains.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS045790-01A2
Application #
6874594
Study Section
Special Emphasis Panel (ZRG1-IFCN-E (03))
Program Officer
Oliver, Eugene J
Project Start
2004-12-05
Project End
2008-11-30
Budget Start
2004-12-05
Budget End
2005-11-30
Support Year
1
Fiscal Year
2005
Total Cost
$348,031
Indirect Cost
Name
Baylor College of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Solway, Alec; Lohrenz, Terry; Montague, P Read (2017) Simulating future value in intertemporal choice. Sci Rep 7:43119
Kirk, Ulrich; Gu, Xiaosi; Sharp, Carla et al. (2016) Mindfulness training increases cooperative decision making in economic exchanges: Evidence from fMRI. Neuroimage 138:274-283
Kirk, Ulrich; Gu, Xiaosi; Harvey, Ann H et al. (2014) Mindfulness training modulates value signals in ventromedial prefrontal cortex through input from insular cortex. Neuroimage 100:254-62
Kishida, Kenneth T; Montague, P Read (2013) Economic probes of mental function and the extraction of computational phenotypes. J Econ Behav Organ 94:234-241
Kishida, Kenneth T; Yang, Dongni; Quartz, Karen Hunter et al. (2012) Implicit signals in small group settings and their impact on the expression of cognitive capacity and associated brain responses. Philos Trans R Soc Lond B Biol Sci 367:704-16
Kishida, Kenneth T; Montague, P Read (2012) Imaging models of valuation during social interaction in humans. Biol Psychiatry 72:93-100
Kirk, Ulrich; Harvey, Ann; Montague, P Read (2011) Domain expertise insulates against judgment bias by monetary favors through a modulation of ventromedial prefrontal cortex. Proc Natl Acad Sci U S A 108:10332-6
Harvey, Ann H; Kirk, Ulrich; Denfield, George H et al. (2010) Monetary favors and their influence on neural responses and revealed preference. J Neurosci 30:9597-602
Helekar, Santosh A; Shin, Jae C; Mattson, Brandi J et al. (2010) Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis. Front Hum Neurosci 4:219
Salas, Ramiro; Baldwin, Philip; de Biasi, Mariella et al. (2010) BOLD Responses to Negative Reward Prediction Errors in Human Habenula. Front Hum Neurosci 4:36

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