Primary torsion dystonia (PTD) is a chronic movement disorder manifested clinically by focal or generalized sustained muscle contractions, postures, and/or involuntary movements, ranging from action-induced dystonic symptoms to disabling, generalized dystonia. The most frequent genetic variant of PTD is an autosomal dominant mutation mapping to the DYT1 gene on chromosome 9q34 within the coding area for torsin A. However, the pathophysiological link between mutant torsin A and disease manifestation remains unknown. We have developed an integrated psychophysical and multimodal imaging approach to identify abnormal brain-behavior relationships in basal ganglia disease, and to assess their potential reversal with treatment. In the proposed studies, we plan to use this approach to perform an in-depth characterization of functional/anatomical connectivity in subjects expressing genes for primary dystonia. The overarching goal of this work will be to compare learning and related brain function in clinically manifesting and nonmanifesting carriers of the majopr genotypes associated with PTD, DYT1 and the DYT6 mutations in North American Mennonites. Our hypothesis, based on our preliminary data, is that PTD is associated with a functional/anatomical disorder of fronto-striatal pathways, and that this abnormality is more extensive in affecteds as compared with non-manifesting dystonia gene carriers. Group differences in the functional organization of the brain during sequence learning will be assessed using PET imaging. Complementary examinations of anatomical connectivity will be conducted in the same subjects using diffusion tensor imaging (DTI), a novel magnetic resonance technique for the assessment of the direction and integrity of fiber tracts. The role of striatal D2 receptor binding in the development of functional abnormalities in basal ganglia output pathways and in concomitant manifestations will be assessed in both PTD mutation carriers. Lastly, we will use our psychophysical/PET approach in conjunction with deep brain stimulation (DBS) to determine the degree to which motor and non-motor functioning can be reversed through treatment. Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS047668-01A1
Application #
6824293
Study Section
Clinical Neuroscience and Disease Study Section (CND)
Program Officer
Tagle, Danilo A
Project Start
2004-09-20
Project End
2008-06-30
Budget Start
2004-09-20
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$776,808
Indirect Cost
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030
Niethammer, Martin; Carbon, Maren; Argyelan, Miklos et al. (2011) Hereditary dystonia as a neurodevelopmental circuit disorder: Evidence from neuroimaging. Neurobiol Dis 42:202-9
Carbon, Maren; Argyelan, Miklos; Ghilardi, Maria Felice et al. (2011) Impaired sequence learning in dystonia mutation carriers: a genotypic effect. Brain 134:1416-27
Carbon, M; Argyelan, M; Eidelberg, D (2010) Functional imaging in hereditary dystonia. Eur J Neurol 17 Suppl 1:58-64
Carbon, Maren; Argyelan, Miklos; Habeck, Christian et al. (2010) Increased sensorimotor network activity in DYT1 dystonia: a functional imaging study. Brain 133:690-700
Carbon, M; Niethammer, M; Peng, S et al. (2009) Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia. Neurology 72:2097-103
Carbon, M; Eidelberg, D (2009) Abnormal structure-function relationships in hereditary dystonia. Neuroscience 164:220-9
Ma, Yilong; Tang, Chengke; Moeller, James R et al. (2009) Abnormal regional brain function in Parkinson's disease: truth or fiction? Neuroimage 45:260-6
Argyelan, Miklos; Carbon, Maren; Niethammer, Martin et al. (2009) Cerebellothalamocortical connectivity regulates penetrance in dystonia. J Neurosci 29:9740-7
Carbon, Maren; Ghilardi, Maria Felice; Argyelan, Miklos et al. (2008) Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study. Brain 131:146-54
Carbon, Maren; Kingsley, Peter B; Tang, Chengke et al. (2008) Microstructural white matter changes in primary torsion dystonia. Mov Disord 23:234-9

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