The enormous potential of fMRI as a tool for understanding the influences of TBI (Traumatic Brain Injury) on cognitive and motor functioning in humans has begun to be realized as a body of neurocognitive TBI literature has started to emerge (McAllister et al., 1999;2001, Christodoulou et al., 2001). While the consistency in these findings has been encouraging, the validity of conclusions regarding the influences of TBI on brain activation patterns measured by fMRI will be dependent upon better characterizing the wide variability in brain activation patterns observed (Hillary, Steffener, Biswal et al., 2002).
The aim of our proposal is to systematically examine and quantify the vascular and neural factors contributing to trauma- related changes in the fMRI signal. To the best of our knowledge, this is the first attempt to comprehensively examine the biophysical, neural, and cognitive contributions to TBI-related differences in fMRI activation. The techniques we propose to develop and utilize here can be implemented by other investigators to accurately isolate hemodynamic changes due to trauma-related (or, indeed, any population-related) differences in neural activity. Because of this, the current proposal provides the opportunity to establish new standards for applying BOLD fMRI to clinical samples.. The present project intends to combine basic science, engineering, and computational issues to specifically elucidate mechanisms (neuronal vs vascular) that results in TBI subjects having altered brain activation in comparison to healthy controls. Results obtained from the noninvasive technique (fMRI) would provide ways to measure a number of relevant physiological factors and characterize them biophysically to understand human brain function with TBI. Methods and techniques developed can also be used to study between two or more different groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS049176-04
Application #
7647945
Study Section
Clinical Neuroscience and Disease Study Section (CND)
Program Officer
Hicks, Ramona R
Project Start
2006-08-02
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2009
Total Cost
$344,040
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107
Yuan, Rui; Taylor, Paul A; Alvarez, Tara L et al. (2017) MAPBOT: Meta-analytic parcellation based on text, and its application to the human thalamus. Neuroimage 157:716-732
Yuan, Rui; Di, Xin; Taylor, Paul A et al. (2016) Functional topography of the thalamocortical system in human. Brain Struct Funct 221:1971-84
Yuan, Rui; Di, Xin; Kim, Eun H et al. (2013) Regional homogeneity of resting-state fMRI contributes to both neurovascular and task activation variations. Magn Reson Imaging 31:1492-500
Lee, Sang H; Lim, Johan; Park, DoHwan et al. (2012) Input permutation method to detect active voxels in fMRI study. Magn Reson Imaging 30:1495-504
Alvarez, Tara L; Kim, Eun H; Vicci, Vincent R et al. (2012) Concurrent vision dysfunctions in convergence insufficiency with traumatic brain injury. Optom Vis Sci 89:1740-51
Alkan, Yelda; Biswal, Bharat B; Alvarez, Tara L (2011) Differentiation between vergence and saccadic functional activity within the human frontal eye fields and midbrain revealed through fMRI. PLoS One 6:e25866
Alkan, Yelda; Alvarez, Tara L; Gohel, Suril et al. (2011) Functional connectivity in vergence and saccade eye movement tasks assessed using Granger Causality analysis. Conf Proc IEEE Eng Med Biol Soc 2011:8114-7
Kannurpatti, Sridhar S; Motes, Michael A; Rypma, Bart et al. (2011) Non-neural BOLD variability in block and event-related paradigms. Magn Reson Imaging 29:140-6
Motes, Michael A; Biswal, Bharat B; Rypma, Bart (2011) Age-Dependent Relationships between Prefrontal Cortex Activation and Processing Efficiency. Cogn Neurosci 2:1-10
Qian, Chencan; Di, Xin (2011) Phase or amplitude? The relationship between ongoing and evoked neural activity. J Neurosci 31:10425-6

Showing the most recent 10 out of 22 publications