The overall goal of this project is to further develop and evaluate a novel, non-invasive imaging and analysis method for the detection and localization of transient, repeated, but irregular changes in brain activity using functional Magnetic Resonance Imaging (fMRI). The method, 2dTCA, is based on the Temporal Clustering Analysis (TCA) of series of fMRI images and will be developed primarily to detect and localize interictal brain activity in focal epilepsy. In the proposed work, the 2dTCA image analysis algorithms and fMRI imaging protocol will first be evaluated and validated in control studies in human subjects where the timing of the stimulus is known. The validated protocol will then be performed with simultaneous electroencephalogram (EEG) recordings in two cohorts of focal epilepsy patients, (1) those with unilateral ictal discharges on scalp EEG, and (2) those with bilateral ictal discharges on scalp EEG. These data will be used to determine the relationship between the blood oxygenation responses detected and localized by fMRI and 2dTCA alone, the blood oxygenation responses identified by fMRI and simultaneous EEG, and the EEG activity at the scalp. In addition, quantitative analyses of the EEG patterns will be used to identify features of the EEG signals that may be initiating and correspond to the 2dTCA detected oxygenation response. The ultimate outcomes of the proposed study will be (1) a novel and much more clinically practical technique for detection and localization of random, transient BOLD signals that would expand analysis methods for examining interictal (between seizure) activity in epilepsy, as well as other involuntary activation models such as tics in Tourette Syndrome and hallucinations in patients with schizophrenia, and (2) a more complete understanding of the epileptic interictal activity detected by 2dTCA and its relationship to scalp EEG. This study is the foundation of a comprehensive clinical validation in the use of 2dTCA and fMRI in the identification of the seizure focus in epilepsy. If successful, the ability to utilize the spatial localization capabilities of fMRI will be available to those majority of clinical sites that cannot afford MRI-compatible EEG systems and the technical expertise required to use them, and for those patients whose lack of sufficient activity on scalp EEG prohibits the use of the simultaneous EEG methods.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS055822-03
Application #
7643076
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Babcock, Debra J
Project Start
2007-09-30
Project End
2012-06-30
Budget Start
2009-07-01
Budget End
2012-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$268,625
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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Holmes, Martha; Folley, Bradley S; Sonmezturk, Hasan H et al. (2014) Resting state functional connectivity of the hippocampus associated with neurocognitive function in left temporal lobe epilepsy. Hum Brain Mapp 35:735-44
Holmes, Martha J; Yang, Xue; Landman, Bennett A et al. (2013) Functional networks in temporal-lobe epilepsy: a voxel-wise study of resting-state functional connectivity and gray-matter concentration. Brain Connect 3:22-30
Morgan, Victoria L; Sonmezturk, Hasan H; Gore, John C et al. (2012) Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia 53:1628-35
Morgan, Victoria L; Rogers, Baxter P; Sonmezturk, Hasan H et al. (2011) Cross hippocampal influence in mesial temporal lobe epilepsy measured with high temporal resolution functional magnetic resonance imaging. Epilepsia 52:1741-9
Sonmezturk, Hasan H; Morgan, Victoria; Abou-Khalil, Bassel (2011) Focal seizure propagation illustrated by fMRI. Epileptic Disord 13:92-5
Morgan, Victoria L; Gore, John C; Abou-Khalil, Bassel (2010) Functional epileptic network in left mesial temporal lobe epilepsy detected using resting fMRI. Epilepsy Res 88:168-78
Rogers, Baxter P; Katwal, Santosh B; Morgan, Victoria L et al. (2010) Functional MRI and multivariate autoregressive models. Magn Reson Imaging 28:1058-65
Morgan, Victoria L; Gore, John C (2009) Detection of irregular, transient fMRI activity in normal controls using 2dTCA: comparison to event-related analysis using known timing. Hum Brain Mapp 30:3393-405
Morgan, Victoria L; Gore, John C; Szaflarski, Jerzy P (2008) Temporal clustering analysis: what does it tell us about the resting state of the brain? Med Sci Monit 14:CR345-52