The ability to recognize and use objects according to their function (e.g., fork, hammer, pencil) requires coordinated processing across multiple brain regions in temporal, occipital and parietal cortex. Regions in the left parietal lobule are known t support critical aspects of object-directed action, such as grasping and object manipulation. It is known that stroke lesions affecting the left parietal lobule can cause impairments to the ability t manipulate objects correctly according to their function. However, it is not known whether cortical lesions introduced in parietal areas during neurosurgical procedures to remove brain tumors lead to the same types of action impairments. The central clinical goal of this research activity is to carry out the foundational study to determine whether or not corticectomy of parieta cortex to remove brain tumors causes neuropsychological impairments for action knowledge, and whether presurgical functional magnetic resonance imaging (fMRI) provides useful information for mitigating such impairments. The research activity also uses a combination of fMRI and behavioral measures in neurosurgery patients, collected before and after their surgery, to draw causal inferences about how action knowledge is organized and processed in the human brain. The central scientific goal of this research activity is to test a neurocognitive model about how action information is represented in parietal cortex and how it is accessed from visual input. Specific hypotheses are tested about how action representations in the parietal lobule interact in online processing (Aim#1), how visual processing of an object is communicated to parietal action representations (Aim#2), and how action information is stored in parietal cortex (Aim#3). This research program serves two broad goals. First, it will generate a new type of feedback about patient outcome to neurosurgeons that will inform future surgical planning for resection of brain tumors. Importantly, we not only determine whether action impairments are associated with parietal corticectomy, but also test the efficacy of a specific presurgical fMRI protocol for guiding the surgical resection and mitigating the likelihood of disabling action impairments after surgery. Second, hypotheses about the neural organization of object-directed action knowledge are tested, and causal inferences are drawn about the brain processes that support our ability to recognize and manipulate objects according to their function. The results of these investigations have implications for understanding how parietal action systems recover from cortical damage generally (e.g., stroke, TBI). In addition, studying the restricted domain of object- directed action, which has well-established neural substrates, will advance our general understanding of how a brain lesion alters functioning within a broader network, and how network function relates to behavior.
Functional MRI is used to test hypotheses about the cortical networks supporting object-directed action knowledge in neurosurgery patients with brain tumors. In addition, a prognostic metric that combines fMRI and neuropsychological data will be developed for planning the location of corticectomies.
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| Prentiss, Emily K; Schneider, Colleen L; Williams, Zoë R et al. (2018) Spontaneous in-flight accommodation of hand orientation to unseen grasp targets: A case of action blindsight. Cogn Neuropsychol 35:343-351 |
| Garcea, Frank E; Chen, Quanjing; Vargas, Roger et al. (2018) Task- and domain-specific modulation of functional connectivity in the ventral and dorsal object-processing pathways. Brain Struct Funct 223:2589-2607 |
| Chen, Quanjing; Garcea, Frank E; Almeida, Jorge et al. (2017) Connectivity-based constraints on category-specificity in the ventral object processing pathway. Neuropsychologia 105:184-196 |
| Mahon, Bradford Z; Costa, Albert (2017) Theoretical and methodological issues for twenty-first century cognitive neuropsychology. Cogn Neuropsychol 34:395-396 |
| Koopman, Sarah E; Mahon, Bradford Z; Cantlon, Jessica F (2017) Evolutionary Constraints on Human Object Perception. Cogn Sci 41:2126-2148 |
| Garcea, Frank E; Chernoff, Benjamin L; Diamond, Bram et al. (2017) Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing. Curr Biol 27:2684-2691.e7 |
| Chen, Quanjing; Garcea, Frank E; Mahon, Bradford Z (2016) The Representation of Object-Directed Action and Function Knowledge in the Human Brain. Cereb Cortex 26:1609-18 |
| Kersey, Alyssa J; Clark, Tyia S; Lussier, Courtney A et al. (2016) Development of Tool Representations in the Dorsal and Ventral Visual Object Processing Pathways. Cereb Cortex 26:3135-45 |
| Mahon, Bradford Z; Navarrete, Eduardo (2016) Modelling lexical access in speech production as a ballistic process. Lang Cogn Neurosci 31:521-523 |
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