Magnetic Resonance Imaging (MRI) is a flexible and powerful technology for quantifying the effects of many conditions, including numerous neurological disorders, on human brain anatomy, connectivity, vasculature, chemical composition, physiology and function. In the past 15 years, several open source tools have been developed that accurately and automatically segment an array of brain structures. In this project, we seek the resources to extend this set to enable the quantification of neuroanatomical changes that are critical to diagnosing, staging and assessing the efficacy of potential therapeutic interventions in diseases such as Alzheimer?s and Parkinson?s. This includes the acquisition of datasets to enable manual labeling of structures of interest, the generation of documentation, tutorials, unit tests, regression tests and system tests to harden the tools and make them usable by clinicians and neuroscientists, and finally the distribution and support of the data, manual labelings and tools to the more than 32,000 researchers that use FreeSurfer through our existing open source mechanism.

Public Health Relevance

Successful completion of the proposed project will greatly increase the number of structures and level of detail of publicly available segmentation tools. These new capabilities well enable other studies to significantly increase their ability to detect disease effects in research settings as well as phase II and phase III clinical trials. PHS 398 /2590(Rev. 09/04) Page _39___ (continued)

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS105820-02
Application #
9821216
Study Section
Neuroscience and Ophthalmic Imaging Technologies Study Section (NOIT)
Program Officer
Babcock, Debra J
Project Start
2018-12-01
Project End
2023-11-30
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114