Abstract

This application requests funding for a Competitive Renewal of this project. The overall goal of this continuing research is to improve the value of two non-human primate species for research on the genetic factors that influence common complex human diseases such as osteoporosis, hypertension, atherosclerosis and others. The two primate species to be investigated are baboons (Papio hamadryas) and vervet monkeys (Cercopithecus aethiops). Each of these species is used as an animal model for studies of common complex human diseases. This research plan will generate significant new information concerning genetic variability in both species, and includes gene mapping studies in the baboons.
Three Specific Aims are proposed.
The first Aim i s to improve the value of baboons as animal models by adding additional polymorphic microsatellite loci to the preliminary genetic linkage map that is available. The average distance between genetic markers in the map will be reduced and large gaps (greater than 20 centiMorgans) will be filed by identifying and genotyping new baboon DNA polymorphisms in 694 pedigreed animals.
Specific Aim 2 is to add 15 functional genes to the same baboon genetic map, using linkage analysis in the same pedigree. The genes will be chosen for their relevance to human disease.
The third Aim i s to create new opportunities for genetic research by completing paternity exclusion analyses on the UCLA-Sepulveda VA colony of vervet monkeys. The complete genealogy for more than 500 vervets, involving animals from 5 generations, will be determined from a combination of existing records and new genetic data. This will dramatically increase the value of these animals for biomedical research. In summary, this project will crease unique new opportunities for genetic research related to common human health problems by providing new information concerning genetic variation in and gnomic maps of two widely used laboratory primate species.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR008781-08
Application #
6394630
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Robinson, Jerry
Project Start
1993-09-30
Project End
2002-06-30
Budget Start
2001-04-15
Budget End
2002-06-30
Support Year
8
Fiscal Year
2001
Total Cost
$259,787
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Johnson, Zachary; Brent, Linda; Alvarenga, Juan Carlos et al. (2015) Genetic influences on response to novel objects and dimensions of personality in Papio baboons. Behav Genet 45:215-27
Vinson, A; Curran, J E; Johnson, M P et al. (2011) Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors. Atherosclerosis 217:387-94
Vinson, Amanda; Mahaney, Michael C; Diego, Vince P et al. (2008) Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet. J Lipid Res 49:1295-302
Vinson, A; Mahaney, M C; Cox, L A et al. (2008) A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors. Atherosclerosis 196:667-73
Bertin, Angeline; Mahaney, Michael C; Cox, Laura A et al. (2007) Quantitative trait loci for peripheral blood cell counts: a study in baboons. Mamm Genome 18:361-72
Raveendran, Muthuswamy; Harris, R Alan; Milosavljevic, Aleksandar et al. (2006) Designing new microsatellite markers for linkage and population genetic analyses in rhesus macaques and other nonhuman primates. Genomics 88:706-10
Dudley, Christopher J; Hubbard, Gene B; Moore, Charleen M et al. (2006) A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype. Am J Med Genet A 140:94-7
Cox, Laura A; Mahaney, Michael C; Vandeberg, John L et al. (2006) A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. Genomics 88:274-81
Havill, L M; Cox, L A; Rogers, J et al. (2005) Cross-species replication of a serum osteocalcin quantitative trait locus on human chromosome 16q in pedigreed baboons. Calcif Tissue Int 77:205-11

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