The long term objective of this research is the development of compact, robust, and user friendly femtosecond-pulse laser sources for applications in biology and medicine. Examples include multi-photon microscopy, optical coherence tomography imaging and femtosecond corneal surgery. Such sources will provide researchers in the biological and biophysical sciences much greater access to new techniques while enhancing and expanding their capabilities. The primary aim is to develop high-energy fiber lasers and semiconductor lasers. As a result of recent advances in these fields, the development of short-pulse sources with capabilities that will exceed those of bulk solid-state lasers is realistic. Fibers and semiconductors offer the possibility of completely integrated devices, which will be required for new short-pulse techniques to attain widespread use. A secondary focus of this work will be the development and application of measurement capabilities in support of multi-photon microscopy. The goal is to clarify the photo physics underlying multi photon techniques. The development of new and/or enhanced capabilities for visualizing and affecting tissue levels at level ranging from molecular to macroscopic has had obvious health benefits and similar or greater impact can be expected in the future.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR010075-05
Application #
6188385
Study Section
Special Emphasis Panel (ZRG1-DMG (01))
Program Officer
Marron, Michael T
Project Start
1995-08-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
5
Fiscal Year
2000
Total Cost
$199,479
Indirect Cost
Name
Cornell University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
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Ilday, F O; Lim, H; Buckley, J R et al. (2003) Practical all-fiber source of high-power, 120-fs pulses at 1 micrometre. Opt Lett 28:1362-4
Lim, H; Ilday, F O; Wise, F W (2003) Generation of 2-nJ pulses from a femtosecond ytterbium fiber laser. Opt Lett 28:660-2
Liu, X; Beckwitt, K; Wise, F (2000) Transverse instability of optical spatiotemporal solitons in quadratic media. Phys Rev Lett 85:1871-4
Liu, X; Beckwitt, K; Wise, F (2000) Noncollinear generation of optical spatiotemporal solitons and application to ultrafast digital logic. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61:R4722-5