Peripheral vascular disease (PVD) is a chronic disease that afflicts a relatively large fraction of our elderly population. The level of oxygenation of limb muscles is believed to be an important parameter for the diagnosis of PVD. Angiography of the extremities provides anatomical details of blood flow, but limited information on the level of tissue oxygenation. Other non-invasive methods, including laser Doppler, are relatively superficial and do not directly provide the level of tissue oxygen saturation. We have developed a new technology that can provide specific information on the level of oxygen saturation in tissues based on near-ir frequency domain spectroscopy. The optical signal derives from deep penetration of photon density waves in tissue. Recent advances in our laboratory have elucidated the physical modalities of light diffusion in tissues and have allowed, for the first time, the design and construction of non-invasive portable, relatively inexpensive (about $l0K) monitors of tissue oxygen saturation. We have demonstrated that the method is absolute, quantitative, and accurate in model systems. Preliminary tests with our collaborators at the Dallas VA Medical Center on PVD patients have provided evidence that the optical oxygen monitor can be clinically useful. This project aims at the design and engineering refinement of a monitor of hemoglobin saturation for the diagnosis of PVD. Specifically, we plan to validate the method, to assess the reproducibility and accuracy of the measurement in optically heterogeneous realistic phantoms. In conjunction with our studies, the redesigned optical saturation monitor will be tested by the Dallas clinical team on PVD patients. The result of our research should be the design and characterization of an innovative, non-invasive clinical instrument that will provide the clinician with the physiological parameter that is considered to be the meaningful index for the early detection and treatment of PVD.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
1R01RR010966-01
Application #
2286554
Study Section
Biomedical Research Technology Review Committee (BRC)
Project Start
1995-09-01
Project End
1998-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Physics
Type
Schools of Engineering
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Wolf, Ursula; Wolf, Martin; Choi, Jee H et al. (2007) Regional differences of hemodynamics and oxygenation in the human calf muscle detected with near-infrared spectrophotometry. J Vasc Interv Radiol 18:1094-101
Safonova, Larisa P; Michalos, Antonios; Wolf, Ursula et al. (2004) Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy. Arch Gerontol Geriatr 39:207-25
Toronov, Vlad; Walker, Scott; Gupta, Rajarsi et al. (2003) The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. Neuroimage 19:1521-31
Wolf, Ursula; Wolf, Martin; Choi, Jee H et al. (2003) Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry. J Vasc Surg 37:1017-26
Wolf, Martin; Franceschini, Maria A; Paunescu, Lelia A et al. (2003) Absolute frequency-domain pulse oximetry of the brain: methodology and measurements. Adv Exp Med Biol 530:61-73
Wolf, Ursula; Wolf, Martin; Choi, Jee H et al. (2003) Mapping of hemodynamics on the human calf with near infrared spectroscopy and the influence of the adipose tissue thickness. Adv Exp Med Biol 510:225-30
Wolf, Martin; Wolf, Ursula; Choi, Jee H et al. (2003) Detection of the fast neuronal signal on the motor cortex using functional frequency domain near infrared spectroscopy. Adv Exp Med Biol 510:193-7
Wolf, Martin; Wolf, Ursula; Toronov, Vlad et al. (2002) Different time evolution of oxyhemoglobin and deoxyhemoglobin concentration changes in the visual and motor cortices during functional stimulation: a near-infrared spectroscopy study. Neuroimage 16:704-12
Toronov, V; Webb, A; Choi, J H et al. (2001) Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. Med Phys 28:521-7
Toronov, V; Franceschini, M A; Filiaci, M et al. (2000) Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: temporal analysis and spatial mapping. Med Phys 27:801-15

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