The proposed research offers an innovative approach for addressing serious errors encountered in in-vivo glucose monitoring through the rational design of oxygen-independent interference-free fluorocarbon/metalized-carbon enzyme electrodes. The use of perfluorochemicals, often employed as blood substitutes due to their remarkable oxygen solubility, as a major component of the biocomposite electrode, should satisfy the oxygen demand internally. The new catalytic metal-carbon component of the electrode would offer preferential detection of the enzymatically-liberated peroxide species, and freedom from common electroactive interferences. The resulting fluorocarbon/metalized-carbon biocomposite microelectrode will thus possess the high accuracy essential for triggering proper alarms, and for making valid therapeutic decisions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
1R01RR014173-01
Application #
2870412
Study Section
Special Emphasis Panel (ZRG7-SSS-8 (45))
Project Start
1998-09-30
Project End
2001-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
New Mexico State University Las Cruces
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Las Cruces
State
NM
Country
United States
Zip Code
88003
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