Abstract

This project will develop an integrated genetic and genomic resource for investigations of the central nervous system (CNS), metabolism, and immunity. Progress in the past included the completion of a genetic map consisting of microsatellite markers, the identification of large numbers of single nucleotide polymorphisms (SNPs) in targeted genome regions and the generation of an initial resource for gene expression studies. A genome sequencing project is now underway and will provide, in addition to a reference sequence, a reference transcriptome, and genome wide information on common variation. The renewal will use this information to verify genomic rearrangements, and generate a genome wide SNP array. By assembling and then genotyping using this array we will carry out proof-of- concept genome wide association studies of several heritable traits. We will also extend the transcriptome resource through evaluation of inter-individual variation in expression. All of the information generated through this project will be made available to the scientific community through an integrated regularly updated website.

Public Health Relevance

This project will develop research tools which will facilitate a wide range of different investigations that could advance our understanding of a number of devastating common diseases. Notable examples include HIV/AIDS, mental disorders, and diabetes. These tools will allow researchers to uncover specific alterations in the genome - the sum of genetic material - that predispose towards or protect against such diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR016300-08
Application #
7895500
Study Section
Genomics, Computational Biology and Technology Study Section (GCAT)
Program Officer
Harding, John D
Project Start
2001-07-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
8
Fiscal Year
2010
Total Cost
$661,626
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Garcia, Erin I; Emerman, Michael (2018) Recurrent Loss of APOBEC3H Activity during Primate Evolution. J Virol :
Turner, Trudy R; Schmitt, Christopher A; Cramer, Jennifer Danzy et al. (2018) Morphological variation in the genus Chlorocebus: Ecogeographic and anthropogenically mediated variation in body mass, postcranial morphology, and growth. Am J Phys Anthropol 166:682-707
Schmitt, C A; Service, S K; Jasinska, A J et al. (2018) Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus). Int J Obes (Lond) 42:765-774
Jasinska, Anna J; Zelaya, Ivette; Service, Susan K et al. (2017) Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet 49:1714-1721
Svardal, Hannes; Jasinska, Anna J; Apetrei, Cristian et al. (2017) Ancient hybridization and strong adaptation to viruses across African vervet monkey populations. Nat Genet 49:1705-1713
Turner, Trudy R; Coetzer, Willem G; Schmitt, Christopher A et al. (2016) Localized population divergence of vervet monkeys (Chlorocebus spp.) in South Africa: Evidence from mtDNA. Am J Phys Anthropol 159:17-30
Senghore, Madikay; Bayliss, Sion C; Kwambana-Adams, Brenda A et al. (2016) Transmission of Staphylococcus aureus from Humans to Green Monkeys in The Gambia as Revealed by Whole-Genome Sequencing. Appl Environ Microbiol 82:5910-7
Kuokkanen, Satu; Polotsky, Alex J; Chosich, Justin et al. (2016) Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med 62:227-42
Bailey, Adam L; Lauck, Michael; Sibley, Samuel D et al. (2016) Zoonotic Potential of Simian Arteriviruses. J Virol 90:630-5
Turner, Trudy R; Cramer, Jennifer Danzy; Nisbett, Alexis et al. (2016) A comparison of adult body size between captive and wild vervet monkeys (Chlorocebus aethiops sabaeus) on the island of St. Kitts. Primates 57:211-20

Showing the most recent 10 out of 30 publications