By the end of 1999, UNAIDS estimated that the number of children living with HIV/AIDS in hail and was 13,900. Antiretroviral treatment has not yet been implemented. Five-year survival from a limited number of HIV-infected children in Thailand was less than 30%, in contrast to 75% from the US cohort before the era of HAART. The natural history from a large cohort of HIV infected children is essential as baseline information in order to evaluate intervention including antiretroviral treatment. Since 2000, an extensive perinatal HIV prevention program has been implemented throughout Thailand. The HIV perinatal transmission rate is currently approximately 10% The outcome of children born to HIV-infected mothers, both infected and uninfected children, in terms of behavioral and psychosocial aspects are important to identify their special needs. Overall goal of this study is to characterize the natural history of children affected by HIV/AIDS epidemic in Thailand. The comprehensive understanding of natural history in this special population will lead to development of culturally and medically appropriate interventions to improve their quality of life.
The specific aims of this proposal are (1) to characterize the natural history of HIV- infected children in terms of their overall survival and survival after the development of AIDS (2) to compare the natural history of HIV-infected children before and after Pneumocystis carinii prophylaxis has been implemented in 1996. We propose to examine a retrospective cohort of 940 HIV-infected children under medical care of the Department of Pediatrics, Chiang Mai University between 1989- 2001 to address specific aims 1 and 2 (3) to characterize the psychosocial problems and needs of school-aged children born to HIV-infected mothers, both infected and uninfected children (4) to characterize the behavioral outcome of school-aged children born to HIV-infected mothers, both infected and uninfected children. We propose to perform a prospective cohort study of school-aged children born to HIV infected mothers at Chiang Mai University.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project (R01)
Project #
5R01TW006187-04
Application #
6933033
Study Section
Special Emphasis Panel (ZRG1-ICP (02))
Program Officer
Liu, Xingzhu
Project Start
2002-09-24
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
4
Fiscal Year
2005
Total Cost
$54,000
Indirect Cost
Name
Chiang Mai University
Department
Type
DUNS #
660994984
City
Chiang Mai
State
Country
Thailand
Zip Code
50202
Puthanakit, Thanyawee; Aurpibul, Linda; Louthrenoo, Orawan et al. (2010) Poor cognitive functioning of school-aged children in thailand with perinatally acquired HIV infection taking antiretroviral therapy. AIDS Patient Care STDS 24:141-6
Aurpibul, Linda; Puthanakit, Thanyawee; Lee, Benjamin et al. (2007) Lipodystrophy and metabolic changes in HIV-infected children on non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy. Antivir Ther 12:1247-54
Puthanakit, Thanyawee; Aurpibul, Linda; Oberdorfer, Peninnah et al. (2007) Hospitalization and mortality among HIV-infected children after receiving highly active antiretroviral therapy. Clin Infect Dis 44:599-604
Puthanakit, Thanyawee; Oberdorfer, Peninnah; Akarathum, Noppadon et al. (2006) Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected thai children. Pediatr Infect Dis J 25:53-8
Puthanakit, Thanyawee; Oberdorfer, Peninnah; Ukarapol, Nuthapong et al. (2006) Immune reconstitution syndrome from nontuberculous mycobacterial infection after initiation of antiretroviral therapy in children with HIV infection. Pediatr Infect Dis J 25:645-8
Puthanakit, Thanyawee; Oberdorfer, Penninah; Punjaisee, Suchart et al. (2005) Immune reconstitution syndrome due to bacillus Calmette-Guerin after initiation of antiretroviral therapy in children with HIV infection. Clin Infect Dis 41:1049-52
Sanmaneechai, Oranee; Puthanakit, Thanyawee; Louthrenoo, Orawan et al. (2005) Growth, developmental, and behavioral outcomes of HIV-affected preschool children in Thailand. J Med Assoc Thai 88:1873-9