China is facing a double challenge of both HIV/AIDS and drug abuse epidemics. Injection drug users (IDUS) are the driving force of HIV/AIDS epidemics and female injection drug users appear to be at higher risk for HIV infection. In recent years, scientific knowledge about gender-related differences in drug use and HIV/AIDS has increased, but in China, such information is absent although drug use among women and HIV infection is increasing rapidly. The available studies done in China on HIV/AIDS and IDUs are cross-sectional investigations in high HIV prevalence rural areas; few studies have been done in urban areas. In order to fill these gaps on information, we propose a longitudinal study to understand the gender difference of HIV risk behaviors and drug use among IDUs in Shanghai, China, an area with a low prevalence of HIV infection. This prospective epidemiological research will focus specifically on exploring gender effects on changes of HIV risk behaviors and the prevalence and incidence of HIV, HCV and HBV infections and factors lead to HIV incidence during a 24 month follow-up period by conducting both qualitative and quantitative studies. This study also will allow us to determine whether the low HIV prevalence will be maintained during a 24 month follow-up period and will explore factors that contribute to the low HIV prevalence rate in Shanghai. This kind of research will be very important to fill the research gap in China and the insights from it will provide very important information for effective HIV/AIDS surveillance and intervention strategies. Based on this study, effective HIV/AIDS prevention/intervention and drug treatment programs in China may be planned and implemented to decrease the HIV epidemic among IDUs and prevent the potential for the transmission of HIV infection from high risk groups such as IDUs to other populations. This proposal is the result of collaborative efforts among a NIDA-supported foreign research trainee upon returning to her home institution at Shanghai Mental Health Center and her mentors at University of Miami, and it will lead to further expansion of collaboration on HIV/AIDS and drug abuse research between Shanghai and Miami. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project (R01)
Project #
5R01TW007279-03
Application #
7414439
Study Section
Special Emphasis Panel (ZRG1-ICP-3 (51))
Program Officer
Liu, Xingzhu
Project Start
2006-08-01
Project End
2011-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
3
Fiscal Year
2008
Total Cost
$50,177
Indirect Cost
Name
Shanghai Mental Health Center
Department
Type
DUNS #
529090854
City
Shanghai
State
Country
China
Zip Code
20003-0
Su, Hang; Li, Zhibin; Du, Jiang et al. (2015) Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China. Am J Med Genet B Neuropsychiatr Genet 168:712-9
Du, Jiang; Wang, Zhen; Xie, Bin et al. (2012) Hepatitis C knowledge and alcohol consumption among patients receiving methadone maintenance treatment in Shanghai, China. Am J Drug Alcohol Abuse 38:228-32
Li, Ting; Du, Jiang; Yu, Shunying et al. (2012) Pathways to age of onset of heroin use: a structural model approach exploring the relationship of the COMT gene, impulsivity and childhood trauma. PLoS One 7:e48735
Zhao, Min; Fan, Chenglu; Du, Jiang et al. (2012) Cue-induced craving and physiological reactions in recently and long-abstinent heroin-dependent patients. Addict Behav 37:393-8
Zhao, Min; Ling, Walter (2012) HIV/AIDS and drug use in China--interactions, impacts, and issues. Subst Use Misuse 47:1015-25
Du, Jiang; Lombardi, Christina; Evans, Elizabeth et al. (2012) A mixed methods approach to identifying factors related to voluntary HIV testing among injection drug users in Shanghai, China. Int J Infect Dis 16:e498-503
Min, Zhao; Xu, Li; Chen, Hanhui et al. (2011) A pilot assessment of relapse prevention for heroin addicts in a Chinese rehabilitation center. Am J Drug Alcohol Abuse 37:141-7
Li, Ting; Yu, Shunying; Du, Jiang et al. (2011) Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. PLoS One 6:e22923
Wang, Zhen; Du, Jiang; Sun, Haiming et al. (2010) Patterns of childhood trauma and psychological distress among injecting heroin users in China. PLoS One 5:e15882