Previous research indicates inter-relationships among cancer risk, DNA repair and antioxidants, including vitamin E. However, controlled data in humans on the relationship of DNA repair to vitamin E is lacking. In this randomized controlled trial humans with prior colorectal polyps, we test whether vitamin E will modulate DNA repair measures (ADPRT, UDS and O6MGT) in lymphocytes and in monocytes obtained from peripheral blood. For final analysis, there will be a total sample size of 52 with good compliance. Each participant will have 2 baseline measures of DNA repair two days apart, then undergo randomization into one of two groups, placebo and vitamin E. The DNA repair measures will be repeated at 1 month and 2 months alter the intervention. There will be 83 % power to detect an effect on the DNA repair measure when the difference in the change in the measure is 25% or greater between the treated and placebo arms.
| Mahabir, Somdat; Frenkel, Krystyna; Brady, Mary Sue et al. (2004) Randomized, placebo-controlled pilot trial of the effects of alpha-tocopherol supplementation on levels of autoantibodies against 5-hydroxymethyl-2-deoxyuridine in melanoma patients. Melanoma Res 14:49-56 |
| Mahabir, S; Coit, D; Liebes, L et al. (2002) Randomized, placebo-controlled trial of dietary supplementation of alpha-tocopherol on mutagen sensitivity levels in melanoma patients: a pilot trial. Melanoma Res 12:83-90 |
