Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
5R03CA066990-02
Application #
2110536
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1995-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Grant, S; Roberts, J; Poplin, E et al. (1998) Phase Ib trial of bryostatin 1 in patients with refractory malignancies. Clin Cancer Res 4:611-8
Wang, S; Guo, C Y; Castillo, A et al. (1998) Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937). Biochem Pharmacol 56:635-44
Wang, Z; Su, Z Z; Fisher, P B et al. (1998) Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells. Exp Cell Res 244:105-16
Freemerman, A J; Vrana, J A; Tombes, R M et al. (1997) Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11:504-13
Wang, S; Vrana, J A; Bartimole, T M et al. (1997) Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. Mol Pharmacol 52:1000-9
Grant, S; Freemerman, A J; Birrer, M J et al. (1996) Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67). Cell Growth Differ 7:603-13
Grant, S; Turner, A J; Freemerman, A J et al. (1996) Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis. Exp Cell Res 228:65-75
Grant, S; Jarvis, W D (1996) Modulation of drug-induced apoptosis by interruption of the protein kinase C signal transduction pathway: a new therapeutic strategy. Clin Cancer Res 2:1915-20
Jarvis, W D; Grant, S; Kolesnick, R N (1996) Ceramide and the induction of apoptosis. Clin Cancer Res 2:1-6
Rao, A S; Freemerman, A J; Jarvis, W D et al. (1996) Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells. Leukemia 10:1150-8