Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
1R03CA072526-01
Application #
2010605
Study Section
Special Emphasis Panel (SRC (77))
Project Start
1996-09-30
Project End
1998-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Endo, S; Zeng, Q; Burke, N A et al. (2000) TGF-alpha antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo. Gene Ther 7:1906-14
Grandis, J R; Drenning, S D; Zeng, Q et al. (2000) Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 97:4227-32
Rubin Grandis, J; Zeng, Q; Drenning, S D (2000) Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope 110:868-74
Grandis, J R; Drenning, S D; Chakraborty, A et al. (1998) Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest 102:1385-92
Drenning, S D; Marcovitch, A J; Johnson, D E et al. (1998) Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res 4:2913-21
Rubin Grandis, J; Tweardy, D J; Melhem, M F (1998) Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin Cancer Res 4:13-20
Rubin Grandis, J; Melhem, M F; Gooding, W E et al. (1998) Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90:824-32
Grandis, J R; Zeng, Q; Drenning, S D et al. (1998) Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol 13:375-8