Abstract

We will develop a general """"""""extended hazard"""""""" spatial survival model to predict geographical effects and geo- graphically varying effects in cancer survival. The proposed model can include the proportional hazards spatial survival model and the accelerated failure time spatial survival model as its special cases. Furthermore, the new model can correctly identify the geographical effects and geographically varying effects in cancer survival. The performance of the proposed model will be evaluated by a comprehensive simulation study. To demonstrate the usage of the proposed model, we will apply the proposed method to analyze prostate cancer within Louisiana from the Surveillance, Epidemiology, and End Results program, and prostate cancer data set from South Carolina Central Cancer Registry (SCCCR). The software development will solve the computational issue in practice and will enable the practitioners and researchers apply the proposed method easily.

Public Health Relevance

We will develop a general """"""""extended hazard"""""""" spatial survival model, which includes current spatial survival models as its special cases, to predict geographical effects and geographically varying effects in cancer survival. Therefore, the proposed model can be used when the proportional hazards assumption is not satisfied. We will conduct a comprehensive simulation study to compare its performances to other existing spatial survival models and apply it to investigate the spatial patterns and racial disparities of prostate cancer in Louisiana and in South Carolina.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
1R03CA165110-01
Application #
8243090
Study Section
Special Emphasis Panel (ZCA1-SRLB-D (O1))
Program Officer
Zhu, Li
Project Start
2012-02-17
Project End
2014-01-31
Budget Start
2012-02-17
Budget End
2013-01-31
Support Year
1
Fiscal Year
2012
Total Cost
$72,500
Indirect Cost
$22,500

  Institution

Name
University of South Carolina at Columbia
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208

  Publications

Li, Li; Hanson, Timothy; Zhang, Jiajia (2015) Spatial extended hazard model with application to prostate cancer survival. Biometrics 71:313-22
Zhou, Haiming; Hanson, Timothy; Jara, Alejandro et al. (2015) MODELLING COUNTY LEVEL BREAST CANCER SURVIVAL DATA USING A COVARIATE-ADJUSTED FRAILTY PROPORTIONAL HAZARDS MODEL. Ann Appl Stat 9:43-68
Chen, Yuhui; Hanson, Timothy; Zhang, Jiajia (2014) Accelerated hazards model based on parametric families generalized with Bernstein polynomials. Biometrics 70:192-201