The specific aims of this project are to localize and identify a gene responsible for the perception of the bitter taste of 6-n-propylthiouraci (PROP) and related compounds. This is to be done by screening the PROP perception of a large population which has been ascertained and is being genotyped for a separate study of obesity genes. Sib pair analysis of informative sibships will be used to localize a gene, and particularly discordant pairs will be further tested to refine the phenotype and perform additional linkage analysis. Haplotyping and association analysis will be use to further narrow the interval likely to contain the gene. The function of genes localized to the region will be examined to determine if they are likely candidates, with particular attention to genes involved in transduction in retinal cells, since there is evidence of homology with the mechanisms of tast receptors. Known variations in such genes will be tested for co-segregation with the PROP phenotype. If there are no known candidate genes, expressed sequences will be similarly evaluated.
| Jiang, Peihua; Josue, Jesusa; Li, Xia et al. (2012) Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A 109:4956-61 |
| Mennella, J A; Finkbeiner, S; Reed, D R (2012) The proof is in the pudding: children prefer lower fat but higher sugar than do mothers. Int J Obes (Lond) 36:1285-91 |
| Knaapila, Antti; Zhu, Gu; Medland, Sarah E et al. (2012) A genome-wide study on the perception of the odorants androstenone and galaxolide. Chem Senses 37:541-52 |
| Lipchock, Sarah V; Reed, Danielle R; Mennella, Julie A (2012) Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis. Clin Ther 34:728-33 |
| Lipchock, Sarah V; Reed, Danielle R; Mennella, Julie A (2011) The gustatory and olfactory systems during infancy: implications for development of feeding behaviors in the high-risk neonate. Clin Perinatol 38:627-41 |
| Mennella, Julie A; Pepino, Marta Yanina; Duke, Fujiko F et al. (2011) Psychophysical dissection of genotype effects on human bitter perception. Chem Senses 36:161-7 |
| Li, Xia; Bachmanov, Alexander A; Maehashi, Kenji et al. (2011) Sweet taste receptor gene variation and aspartame taste in primates and other species. Chem Senses 36:453-75 |
| Pelchat, Marcia Levin; Bykowski, Cathy; Duke, Fujiko F et al. (2011) Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study. Chem Senses 36:9-17 |
| Bachmanov, Alexander A; Bosak, Natalia P; Floriano, Wely B et al. (2011) Genetics of sweet taste preferences. Flavour Fragr J 26:286-294 |
| Reed, Danielle Renee; Knaapila, Antti (2010) Genetics of taste and smell: poisons and pleasures. Prog Mol Biol Transl Sci 94:213-40 |
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