Otoacoustic emissions provide a non- invasive window into cochlear function, being presumably a by-product of the action of the cochlear amplifier. This study aims to use otoacoustic emissions to examine the question of propagation time along the cochlear partition; i.e., does the delay of the emission essentially reflect the delay associated with the action of the cochlear mechanical amplifier? The group delay of amplitude- modulated tone-burst evoked otoacoustic emissions will be measured in guinea pigs and humans, the guinea pig data compared with basilar membrane data in an attempt to delineate a """"""""propagation component"""""""", if it exists. This study will also compare measured group delay values with phase-gradient estimate of delays obtained using distortion product otoacoustic emission sweep-frequency paradigms, the thesis being that such paradigms do not provide for travel times within the cochlea.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Small Research Grants (R03)
Project #
1R03DC004921-01A1
Application #
6444323
Study Section
Special Emphasis Panel (ZDC1-SRB-O (24))
Program Officer
Donahue, Amy
Project Start
2002-01-22
Project End
2004-12-31
Budget Start
2002-01-22
Budget End
2002-12-31
Support Year
1
Fiscal Year
2002
Total Cost
$70,025
Indirect Cost
Name
Indiana University Bloomington
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Withnell, Robert H; McKinley, Sarah (2005) Delay dependence for the origin of the nonlinear derived transient evoked otoacoustic emission. J Acoust Soc Am 117:281-91
Goodman, Shawn S; Withnell, Robert H; De Boer, Egbert et al. (2004) Cochlear delays measured with amplitude-modulated tone-burst-evoked OAEs. Hear Res 188:57-69
Withnell, Robert H; Shaffer, Lauren A; Talmadge, Carrick L (2003) Generation of DPOAEs in the guinea pig. Hear Res 178:106-17
Goodman, Shawn S; Withnell, Robert H; Shera, Christopher A (2003) The origin of SFOAE microstructure in the guinea pig. Hear Res 183:7-17
Shaffer, Lauren A; Withnell, Robert H; Dhar, Sumit et al. (2003) Sources and mechanisms of DPOAE generation: implications for the prediction of auditory sensitivity. Ear Hear 24:367-79