The long-term objective of this research is to increase understanding of the relationship between brain changes and behavioral recovery from stroke. Recent studies of the relationship between brain perfusion, lesion size, and early severity of aphasia (language disorder) in stroke suggest that these variables are strongly correlated. It is not clear, however, how changes in cerebral perfusion and lesion size may be related to behavioral recovery following stroke. MRI provides means for quick assessment of cerebral perfusion and lesion size in the acute stages of stroke. Along with behavioral testing, MRI makes it possible to investigate how changes in neurological factors are related to stroke recovery.
The specific aims of this project are to answer the following questions: 1. Do changes in cerebral hypoperfusion and/or lesion size predict recovery from aphasia and hemispatial neglect during the first month following stroke. 2. Does the extent of cerebral hypoperfusion and/or lesion size in acute ischemic stroke predict recovery from aphasia and hemispatial neglect and clinical outcome at one-month post-onset? Answers to these questions will provide insight into how brain changes and behavioral recovery may be related in early stroke. Consequently, they provide means to improve management of early stroke and, subsequently, aphasia and hemispatial neglect. That is, if the extent of behavioral recovery can be predicted based on brain physiology in the acute care [stage?], it is possible that stroke treatment can be better calibrated.
| Fridriksson, Julius; Baker, Julie M; Whiteside, Janet et al. (2009) Treating visual speech perception to improve speech production in nonfluent aphasia. Stroke 40:853-8 |
| Turner, Travis H; Fridriksson, Julius; Baker, Julie et al. (2009) Obligatory Broca's area modulation associated with passive speech perception. Neuroreport 20:492-6 |
| Fridriksson, Julius; Moser, Dana; Ryalls, Jack et al. (2009) Modulation of frontal lobe speech areas associated with the production and perception of speech movements. J Speech Lang Hear Res 52:812-9 |
| Fridriksson, Julius; Moss, Joel; Davis, Ben et al. (2008) Motor speech perception modulates the cortical language areas. Neuroimage 41:605-13 |
| Fridriksson, Julius; Bonilha, Leonardo; Rorden, Chris (2007) Severe Broca's aphasia without Broca's area damage. Behav Neurol 18:237-8 |
| Moser, Dana C; Fridriksson, Julius; Healy, Eric W (2007) Sentence comprehension and general working memory. Clin Linguist Phon 21:147-56 |
| Healy, Eric W; Moser, Dana C; Morrow-Odom, K Leigh et al. (2007) Speech perception in MRI scanner noise by persons with aphasia. J Speech Lang Hear Res 50:323-34 |
| Fridriksson, Julius; Morrow-Odom, Leigh; Moser, Dana et al. (2006) Neural recruitment associated with anomia treatment in aphasia. Neuroimage 32:1403-12 |
| Fridriksson, Julius; Holland, Audrey L; Beeson, Pelagie et al. (2005) Spaced retrieval treatment of anomia. Aphasiology 19:99-109 |
| Fridriksson, Julius; Morrow, Leigh (2005) Cortical activation and language task difficulty in aphasia. Aphasiology 19:239-250 |
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