Chronic pain is a major health problem afflicting patients with a variety of disorders. Current management focuses largely on opiates. However, the vertebrate nervous system has an endogenous system of pain management, and if this could be augmented it would provide new ways of pain management. The principal investigator proposes to transfer the gene for serotonin type-3 (5HT3) receptors to rats by intrathecal injection of an adenovirus vector and test the resulting changes in carrageenan-induced inflammatory pain. The principal investigator will examine the dose-dependence and time course of the effects, and will evaluate cellular mechanisms by which the analgesic effects are produced.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
1R03DE012022-01A1
Application #
2015334
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1997-03-01
Project End
1999-02-28
Budget Start
1997-03-01
Budget End
1998-02-28
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390