This is a proposal to test the hypothesis that the ornithine decarboxylase-antizyme gene (ODC-Az) is a tumor suppressor gene in oral cancer Under Aim 1 the tumor suppressing-potential will be evaluated in malignant hamster oral keratinocytes by introducing the gene in an inducible retrovirus system.
Under Aim 2 the regulatory region of the gene will be examined in orde to find if loss of expression is due to changes in that region.
| Tsuji, T; Usui, S; Aida, T et al. (2001) Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme. Oncogene 20:24-33 |
