Coxsackievirus is a common infection that causes viral myocarditis, meningoencephalitis, and hand, foot, and mouth disease in children and adults. Coxsackievirus is spread by the fecal-oral route and initiates infection in the gastrointestinal tract. There are no therapeutics to Coxsackievirus, in part due to a lack of knowledge in how Coxsackievirus initiates infection in the intestine. We recently developed a mouse model to investigate Coxsackievirus B3 (CVB3) replication in the intestine. Using this model, we found that, similar to humans, male mice succumb to CVB3-induced disease, whereas female mice do not. Intriguingly, CVB3 replication in the intestine of male mice is enhanced compared to female mice. Recent data indicate that non-hormonal factors, such as host genes, play a role in intestinal CVB3 replication. Therefore, the goal of this study is to identify host genes that impact viral replication in the intestine. These studies will shed light on the mechanism of CVB3 replication in the intestine.

Public Health Relevance

Coxsackievirus is a major human pathogen that causes multiple diseases worldwide. Coxsackievirus initiates infection in the mammalian intestine; however, the mechanism for Coxsackievirus replication in the gut remains unclear. The goal of this proposal is to investigate the role of host genetic factors on intestinal Coxsackievirus replication to shed light on human infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Research Grants (R03)
Project #
1R03DK124749-01
Application #
9955477
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Saslowsky, David E
Project Start
2020-03-10
Project End
2022-02-28
Budget Start
2020-03-10
Budget End
2021-02-28
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202