The proposers will investigate the effects of EMFs as a possible co-promoter in the C3H/10T1/2 system using a subline of this system whose expression of the neoplastic phenotype is modulated by the presence of retinoic acid. In particular, they will compare the effects of cells exposed intermittently to EMF to cells exposed continuously. They will measure patterns of p53 and myc expression at the transcriptional level and measure upstream molecular sequelae. They will determine the requirements for transcription factors in the expression of myc and p53, using a combination of reporter genes and electrophoretic mobility shift assays. Their studies will compare effects of EMF to chemical tumor promoters.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Small Research Grants (R03)
Project #
1R03ES008867-01
Application #
2019287
Study Section
Special Emphasis Panel (ZES1-CKS-B (01))
Project Start
1997-01-15
Project End
1998-12-31
Budget Start
1997-01-15
Budget End
1997-12-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032