A large number of human placenta samples have been collected from a multi-racial cohort children health study at the Boston Medical Center and another study entitled """"""""Family and Children of Ukraine"""""""". The work proposed here is a small project aimed at developing a laboratory procedure for the analysis of polybrominated diphenyl ethers (PBDEs) in human placental tissues. The work will include three tasks: analytical method development and validation, examination on the integrity of stored samples, and a preliminary data collection. We will explore the applicability of a matrix solid-phase dispersion (MSPD) method and compare it with the standard and conventional procedures. Analytical sensitivity enhancement will be through the optimization of the GC injection process using a programmable temperature vaporization (PTV) large volume injector. The result of this work will be needed to initiate future comprehensive studies on prenatal exposure of human to PBDEs. A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born. ? ? ?
| National Children’s Study Placenta Consortium; Nanes, Jessica A; Xia, Yulin et al. (2014) Selected persistent organic pollutants in human placental tissue from the United States. Chemosphere 106:20-27 |
| Wei, Hua; Dassanayake, Priyanthi S; Li, An (2010) Parametric evaluation for programmable temperature vaporization large volume injection in gas chromatographic determination of polybrominated diphenyl ethers. Int J Environ Anal Chem 90:535-547 |
| Dassanayake, R M A Priyanthi S; Wei, Hua; Chen, Rachel C et al. (2009) Optimization of the matrix solid phase dispersion extraction procedure for the analysis of polybrominated diphenyl ethers in human placenta. Anal Chem 81:9795-801 |
