Abstract

The CIGTS database and patient files contain an extensive collection of Humphrey 24-2 visual field (VF) information gathered over nine years of follow-up on 607 patients with newly-diagnosed, previously un-treated open-angle glaucoma (OAG). These patients were randomized to initial medical or surgical treatment. This VF resource represents a wealth of longitudinal follow-up data on VF change. The following three aims will be pursued after accessing previously entered data and entering further data from all collected Humphrey 24-2 visual fields: 1. Determine the ways in which intraocular pressure (IOP) control is associated with the best VF outcomes. 2. Evaluate the risk of progressive VF loss among African Americans and whites. 3. Determine the relative impact of factors other than IOP control and race on progressive VF loss. Address age, sex, family history, comorbidities, smoking, alcohol ingestion, refractive error, and baseline VF damage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Research Grants (R03)
Project #
1R03EY015860-01
Application #
6819175
Study Section
Special Emphasis Panel (ZEY1-VSN (06))
Program Officer
Everett, Donald F
Project Start
2004-08-01
Project End
2006-06-30
Budget Start
2004-08-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$229,500
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Chen, Philip P; Musch, David C; Niziol, Leslie M (2011) The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study. J Glaucoma 20:211-4
Musch, David C; Gillespie, Brenda W; Lichter, Paul R et al. (2009) Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors. Ophthalmology 116:200-7
Musch, David C; Gillespie, Brenda W; Niziol, Leslie M et al. (2008) Factors associated with intraocular pressure before and during 9 years of treatment in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 115:927-33
Jampel, Henry D; Frick, Kevin D; Janz, Nancy K et al. (2007) Depression and mood indicators in newly diagnosed glaucoma patients. Am J Ophthalmol 144:238-244
Musch, David C; Gillespie, Brenda W; Niziol, Leslie M et al. (2006) Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol 124:1694-700