description) The pituitary gonadotropins, LH and FSH, are critical modulators of gamete maturation and gonadal steroidogenesis; insight into the molecular mechanisms which control expression of these hormones will contribute to an understanding of normal and abnormal reproductive function. The proposal's specific aims are: 1) to identify the steroidogenic factor-1 (SF-1) interactions that regulate basal LHbeta gene expression; and 2) to confirm the physiologic role of SF-1 in LHbeta gene expression using a transgenic mouse model.
| Horton, C D; Halvorson, L M (2004) The cAMP signaling system regulates LHbeta gene expression: roles of early growth response protein-1, SP1 and steroidogenic factor-1. J Mol Endocrinol 32:291-306 |
| Halvorson, L M; Kaiser, U B; Chin, W W (1999) The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol 13:106-16 |
| Halvorson, L M; Ito, M; Jameson, J L et al. (1998) Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. J Biol Chem 273:14712-20 |
