description) The investigator proposes to identify syk tyrosine phosphorylation sites, determine for each site whether it is tyrosine phosphorylated as a result of syk autophosphory-lation and/or src kinase-mediated transphosphorylation, and analyze the role of the phosphorylation in syk enzymatic activation. The results of this project will provide the foundation for future studies aimed at elucidating the functional role of each of these tyrosine phosphorylations in antigen receptor-mediated signal transduction.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD034717-02
Application #
2403631
Study Section
Population Research Committee (HDPR)
Project Start
1996-07-10
Project End
1998-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Beitz, L O; Fruman, D A; Kurosaki, T et al. (1999) SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J Biol Chem 274:32662-6