description): This prospective case-control study will determine whether the practice of breast-feeding during pregnancy is associated with a change in the composition of early milk and a subsequent decrease in milk volume during the next lactation. Because social taboos in the US discourage women from openly breast-feeding through pregnancy, the study can be more efficiently carried out in Peru. 168 multiparous women living in Lima, Peru will be enrolled. Eighty-four women will be identified who are breast-feeding during the third trimester of pregnancy (cases); 84 controls, who have not breast-fed past the first month of pregnancy will be identified after giving birth and will be matched for interbirth interval and sex of the newborn. Intensity of breast-feeding during the last trimester of pregnancy will be determined for the cases. D2 milk composition and volume will be determined. If breast-feeding during pregnancy alters the subsequent lactation, then it would be hypothesize that case infants; intakes of secretory IgA, IgG, total proteins, fat, lactose, and vitamin A would significantly differ than that of controls. Milk volume intake at 1 mo would be significantly decreased. The results of this study will provide the first information on the biological consequences of lactation-pregnancy overlap in humans, essential information needed to understand the health implications of this widespread but little mentioned practice.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD035183-02
Application #
2674080
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
1997-09-20
Project End
1999-01-22
Budget Start
1998-09-01
Budget End
1999-01-22
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294