This application proposes the use of a genetic approach to define the potential roles of luteinizing hormone releasing hormone (LHRH) and its receptors in the brain. Specifically, the investigator proposes to employ the bacteriophage P1-derived Cre-loxP recombination system in a gene targeting approach to selectively delete the LHRH receptor gene from brain neurons and/or astrocytes, without affecting expression of the gene in endocrine tissues, such as the pituitary gland and ovaries.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
1R03HD035958-01A1
Application #
2662671
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
1998-03-01
Project End
2000-02-29
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006