Stroke is the leading neurologic disorder and a major cause of chronic disability. Functional deficits following stroke can be ameliorated through rehabilitation, but until recently there has been little development of testable models of stroke therapies. Furthermore, despite the identification of several predictors of treatment outcomes, comprehensive models to account for how such variables affect therapy outcomes have not been developed. Constraint-Induced Movement Therapy (CI therapy) is a treatment for chronic stroke hemiparesis that has controlled evidence for efficacy on actual daily living tasks. The treatment was developed from basic neuroscience research that postulates that learned non-use is a major determinant of chronic hemiparesis and can be reversed through intensive practice. The intensive practice is associated with massive cortical reorganization on functional imaging studies. The PIs hypothesize that several cognitive mechanisms are essential to the therapeutic benefits of intensive practice: sustained attention, declarative memory, and emotional regulation. About one-third of patients in the CI therapy clinic demonstrate impaired cognitive regulation or memory disturbances, and they tend to have reduced treatment gains and retention of benefits after discharge. The purpose of this pilot application will be to prospectively assess CI therapy clinic patients on the above cognitive functions, and then through multivariable regression analysis determine their contributions to treatment outcomes in comparison to other predictors of general stroke rehabilitation outcomes (age, lesion findings, stroke severity, pre-treatment function, incontinence). The findings will indicate whether specific cognitive processes are importantly involved with the mechanism hypothesized to account for treatment benefit. Understanding of cognitive contributions to CI therapy benefit will help to propose treatment modifications for patients with behavioral disorders who undergo therapy, and as well to better inform prospective patients of their likely treatment benefit. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
1R03HD042519-01A1
Application #
6608752
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Quatrano, Louis A
Project Start
2003-04-15
Project End
2005-03-31
Budget Start
2003-04-15
Budget End
2004-03-31
Support Year
1
Fiscal Year
2003
Total Cost
$62,700
Indirect Cost
Name
University of Alabama Birmingham
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Woods, Adam J; Mark, Victor W (2007) Convergent validity of executive organization measures on cancellation. J Clin Exp Neuropsychol 29:719-23
Mark, Victor W; Woods, Adam J; Mennemeier, Mark et al. (2006) Cognitive assessment for CI therapy in the outpatient clinic. NeuroRehabilitation 21:139-46
Woods, Adam J; Mennemeier, Mark; Garcia-Rill, Edgar et al. (2006) Bias in magnitude estimation following left hemisphere injury. Neuropsychologia 44:1406-12
Mark, Victor W; Oberheu, Anne Marie; Henderson, Cathy et al. (2005) Ballism after stroke responds to standard physical therapeutic interventions. Arch Phys Med Rehabil 86:1226-33
Mennemeier, Mark; Pierce, Christopher A; Chatterjee, Anjan et al. (2005) Biases in attentional orientation and magnitude estimation explain crossover: neglect is a disorder of both. J Cogn Neurosci 17:1194-211
Mark, V W; Woods, A J; Ball, K K et al. (2004) Disorganized search on cancellation is not a consequence of neglect. Neurology 63:78-84