The pathologic precursors of CV disease are now recognized to begin in childhood. In particular, changes in CV risk factors, individually and in clusters (metabolic syndrome or Syndrome X), occur during growth and maturation in childhood. Birth weight, childhood levels of risk factor variables and parental history of CV disease are associated with risk factors including Syndrome X and the attendant CV diseases in adulthood.
The specific aims of this data analysis application are 1) to apply robust statistical models to determine the longitudinal burden of CV risk factor variables, individually and in cluster, during childhood growth and development; 2) to test the predictability of childhood longitudinal measures of risk variables for developing adult risk factors and their clustering; and 3) to examine the influence of birth weight and parental history of CV disease on the longitudinal measures of risk burden in childhood and the attendant risk in adulthood, using the existing Bogalusa Heart Study database collected over a 30-year period. The Bogalusa Heart Study, a long-term biracial (black-white) epidemiologic study of cardiovascular risk factors from birth through 44 years of age, offers an unparalleled database for achieving these aims. The study cohort includes 5483 subjects who were screened since childhood at least 3 times, with 25,982 observations. A subcohort of 1557 individuals with 3712 observations with birth weight is available for association analysis related to birth weight. Serial data on anthropometry, blood pressure, lipoproteins, insulin and glucose will be used to develop a growth curve model to depict the longitudinal patterns of CV risk variables from childhood to adulthood and a random effects model to calculate total area under the curve (AUC), incremental AUC (total AUC - baseline AUC) and linear slope in blacks and whites and males and females. The findings of the proposed data analyses will extend our knowledge on the evolution of CV risk early in life, and importantly, to the development of preventive strategies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD043820-02
Application #
6729158
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Grave, Gilman D
Project Start
2003-04-01
Project End
2005-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
2
Fiscal Year
2004
Total Cost
$74,250
Indirect Cost
Name
Tulane University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Harville, Emily W; Srinivasan, Sathanur; Chen, Wei et al. (2012) Is the metabolic syndrome a ""small baby"" syndrome?: the bogalusa heart study. Metab Syndr Relat Disord 10:413-21
Camhi, Sarah M; Katzmarzyk, Peter T; Broyles, Stephanie et al. (2010) Predicting adult body mass index-specific metabolic risk from childhood. Metab Syndr Relat Disord 8:165-72
Broyles, Stephanie; Katzmarzyk, Peter T; Srinivasan, Sathanur R et al. (2010) The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana. Pediatrics 125:900-5
Paul, Timir K; Chen, Wei; Srinivasan, Sathanur R et al. (2010) Framingham risk score is associated with femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa heart study). Atherosclerosis 213:627-31
Sisson, Susan B; Katzmarzyk, Peter T; Srinivasan, Sathanur R et al. (2009) Ethnic differences in subcutaneous adiposity and waist girth in children and adolescents. Obesity (Silver Spring) 17:2075-81
Frontini, Maria G; Srinivasan, Sathanur R; Xu, Jihua et al. (2008) Usefulness of childhood non-high density lipoprotein cholesterol levels versus other lipoprotein measures in predicting adult subclinical atherosclerosis: the Bogalusa Heart Study. Pediatrics 121:924-9
Tzou, Wendy S; Douglas, Pamela S; Srinivasan, Sathanur R et al. (2007) Distribution and predictors of carotid intima-media thickness in young adults. Prev Cardiol 10:181-9
Johnson, Heather M; Douglas, Pamela S; Srinivasan, Sathanur R et al. (2007) Predictors of carotid intima-media thickness progression in young adults: the Bogalusa Heart Study. Stroke 38:900-5
Li, S; Chen, W; Srinivasan, S R et al. (2006) Influence of lipoprotein lipase gene Ser447Stop and beta1-adrenergic receptor gene Arg389Gly polymorphisms and their interaction on obesity from childhood to adulthood: the Bogalusa Heart Study. Int J Obes (Lond) 30:1183-8
Bhuiyan, Azad R; Srinivasan, Sathanur R; Chen, Wei et al. (2006) Correlates of vascular structure and function measures in asymptomatic young adults: the Bogalusa Heart Study. Atherosclerosis 189:1-7

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