Although there is growing evidence that developmental dyslexia is characterized by problems in basic sensory processes, there has been little work examining how information processing between the different sensory modalities is affected in this disorder. This is despite the fact that the development of reading and linguistic skills is an inherently cross-modal process, involving the integration of the visual and auditory components of the language representation. Based on the previous literature and our preliminary data, it is our hypothesis that dyslexics will indeed show a disorder in multisensory processing, which will manifest as an abnormally large window of time within which visual and auditory stimuli are bound into a unified percept. To test this hypothesis, and to examine the brain substrates that underlie these altered multisensory processes, we propose to conduct psychophysical and fMRI experiments. These experiments will use a multisensory temporal order judgment task in order to delineate the temporal window of multisensory integration in both dyslexic and normal reading subjects, as well as examining the differential patterns of brain activation in multisensory cortical regions during task performance. Together, the results of this study will serve to further our understanding of the neurophysiological bases of dyslexia. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
7R03HD050860-02
Application #
7176387
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Mccardle, Peggy D
Project Start
2005-07-01
Project End
2007-06-30
Budget Start
2006-01-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$38,438
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Stevenson, Ryan A; Baum, Sarah H; Segers, Magali et al. (2017) Multisensory speech perception in autism spectrum disorder: From phoneme to whole-word perception. Autism Res 10:1280-1290
Powers Iii, Albert R; Hillock-Dunn, Andrea; Wallace, Mark T (2016) Generalization of multisensory perceptual learning. Sci Rep 6:23374
Powers 3rd, Albert R; Hevey, Matthew A; Wallace, Mark T (2012) Neural correlates of multisensory perceptual learning. J Neurosci 32:6263-74
Powers 3rd, Albert R; Hillock, Andrea R; Wallace, Mark T (2009) Perceptual training narrows the temporal window of multisensory binding. J Neurosci 29:12265-74
Wallace, Mark T (2009) Dyslexia: bridging the gap between hearing and reading. Curr Biol 19:R260-2
Hairston, W David; Hodges, Donald A; Burdette, Jonathan H et al. (2006) Auditory enhancement of visual temporal order judgment. Neuroreport 17:791-5