The goal of this proposal is to develop new synthetic methods to incorporate fluorine into organic compounds. The investigators propose to explore two new fluorinating strategies: (i) use of 10-electron Ph2SeF3, PhTeF5 and Ph3BiF2 as novel electrophilic fluorinating agents and (ii) reaction of iodonium species with fluorinated nucleophiles. The investigators also propose to explore a new method for cyclization from allenes and iodonium salts to prepare 2,5-dihydrofurans that may serve as leads for the development of new agents to treat HIV. The investigators also intend to prepare other biologically active compounds such as fluorosteroids, protease and phosphatase inhibitors, and analogs of AZT.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
2R03TW000437-04
Application #
6199677
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Program Officer
Michels, Kathleen M
Project Start
1995-03-01
Project End
2003-06-30
Budget Start
2000-08-01
Budget End
2001-06-30
Support Year
4
Fiscal Year
2000
Total Cost
$38,500
Indirect Cost
Name
University of Utah
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Brel, Valery K; Belsky, Vitaly K; Stash, Adam I et al. (2003) Synthesis and molecular structure of new acyclic analogues of nucleotides with a 1,2-alkadienic skeleton. Org Biomol Chem 1:4220-6