Subtype E HIV occurs in South East Asia and has been found in both injection drug users (IVDUs) and commercial sex workers (CSWs) in central and south Vietnam. In Thailand, Subtypes E and B coexist: Subtype E predominates in heterosexual transmission whereas Subtype B is more common among IVDUs. This pattern is changing, with Subtype E now accounting for two thirds of new infections among Thai IVDUs. Recently, concurrent infections with two different subtypes of HIV and infection with virus that is a recombinant of two subtypes has been reported by several researchers. Sexual mixing of IVDUs and CSWs in Vietnam may have resulted in dual and/or recombinant HIV infection. In this application, the Investigator proposes to look for dual and/or recombinant HIV infection in IVDUs and their spouses in central and southern Vietnam--little HIV infection exists in northern Vietnam--and in CSWs in southwestern Vietnam along the Cambodian border. He and his research associates will also compare HIV subtypes occurring earlier in the epidemic with those occurring in both groups now and over the next three years. This study should provide insight into the shifting nature Type 1 human immunodeficiency viruses as the epidemic progresses in Vietnam and Southeast Asia, which should have import for vaccine development.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
3R03TW000866-02S1
Application #
6088834
Study Section
AIDS and Related Research Study Section 2 (ARRB)
Project Start
1997-07-01
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Farrer, L A (2001) Intercontinental epidemiology of Alzheimer disease: a global approach to bad gene hunting. JAMA 285:796-8