This research will be done primarily in the Slovak Republic at Slovak Medical University, Institute for Preventive and Clinical Medicine in collaboration with Professor Tomas Trnovec as an extension of NIH grant # 1 R01 CA96525. The currently-funded grant establishes a birth cohort for the examination of neurobehavioral and immune developmental effects from prenatal and ongoing exposures to PCB's. The site in eastern Slovakia is one of widespread environmental contamination and body burdens of PCB's are among the highest in the world. The goal of this extension is to focus on deficits in hearing as an adverse outcome. The motivation for a study of oto-toxicity from PCBs is two-fold: animal chronic toxicity studies have shown hearing to be a particularly sensitive neurodevelopmental endpoint in rodents, and a study of school-aged children in this region showed hearing impairments at high serum PCB levels-using several measures: audiometry and oto-acoustic emissions. This proposal therefore extends the parent project with a 36-month examination focusing on hearing function using oto-acoustic emissions and tympanometry. Implementation of the study will involve strengthening the Slovak capacity both for research and public health surveillance, as these are intimately intertwined. Oto-acoustic emissions (OAE) provide an indication of cochlear function, specifically the outer hair cells. Tympanometry is useful to exclude problems related to middle ear pressure, so as to pinpoint sensorineural deficits. Multiple linear regression will be used to assess prenatal and postnatal PCB exposures in relation to outer hair cell electromotility measured using OAE in each ear, and tympanometric measurements. In this FIRCA application, we propose to build upon the existing collaboration, to determine if hearing impairments are observed in early childhood in association with PCB exposures, to distinguish contributions from prenatal vs. postnatal exposures, to examine if the association might be related to disruption of thyroid hormone homeostasis, and finally, to evaluate whether there is an association that is stronger for PCB metabolites than for the parent compounds. In short, this proposed add-on will provide the most extensive data yet on developmental ototoxicity from PCBs and will strengthen the research capacity in Slovakia. ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
1R03TW007152-01A1
Application #
7049966
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Program Officer
Primack, Aron
Project Start
2006-02-01
Project End
2009-01-31
Budget Start
2006-02-01
Budget End
2007-01-31
Support Year
1
Fiscal Year
2006
Total Cost
$37,748
Indirect Cost
Name
University of California Davis
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Santos, Susana; Eekhout, Iris; Voerman, Ellis et al. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Med 16:201
Palkovi?ová Murínová, ?ubica; Wimmerová, So?a; Lancz, Kinga et al. (2017) Partitioning of hexachlorobenzene between human milk and blood lipid. Environ Pollut 229:994-999
Koštiaková, Vladimíra; Moleti, Arturo; Wimmerová, So?a et al. (2016) DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows. Chemosphere 161:518-526
Palkovi?ová Murínová, ?ubica; Moleti, Arturo; Sisto, Renata et al. (2016) PCB exposure and cochlear function at age 6 years. Environ Res 151:428-435
Wimmerová, So?a; van den Berg, Martin; Chovancová, Jana et al. (2016) Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on cytochrome P450 1A1 and 1B1 gene expression in blood. Environ Int 96:24-33
Sisto, Renata; Moleti, Arturo; Palkovi?ová Murínová, ?ubica et al. (2015) Environmental exposure to organochlorine pesticides and deficits in cochlear status in children. Environ Sci Pollut Res Int 22:14570-8
Lancz, Kinga; Hertz-Picciotto, Irva; Jusko, Todd A et al. (2015) Duration of breastfeeding and serum PCB 153 concentrations in children. Environ Res 136:35-9
Jusko, Todd A; Sisto, Renata; Iosif, Ana-Maria et al. (2014) Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age. Environ Health Perspect 122:1246-52
Jusko, Todd A; Sonneborn, Dean; Palkovicova, Lubica et al. (2012) Pre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants. Environ Health Perspect 120:595-600
Trnovec, Tomás; Sovcíková, Eva; Pavlovcinová, Gabriela et al. (2010) Serum PCB concentrations and cochlear function in 12-year-old children. Environ Sci Technol 44:2884-9

Showing the most recent 10 out of 12 publications