This grant proposal is specifically addressed to the NIH """"""""Academic Research Enhancement Award"""""""" (AREA PA-97-052). This proposal has identified strategies to address a significant problem in craniofacial orthopedics, what sorts of forces are involved in moving craniofacial bones, and how best they should be applied. The applicant seeks support for pilot research studies with methods the Principal Investigator has designed. The overall goal of the present proposal is to determine whether compressive cyclic forces with certain characteristics, yet to be determined (here), induce bone resorption more effectively than static forces that compress craniofacial sutures in growing rabbits. A working range of parameters of compressive cyclic and static forces will be determined by quantifying the magnitude, mode and rate of in vivo bone strain induced by these forces in rabbit craniofacial bones. Following chronic loading with selected cyclic and static force parameters, alteration of bone contour in the sagittal dimension will be determined by marker-orientated cephalometric radiography. In vivo bone strain adjacent to craniofacial sutures will be determined, followed by quantification of vital-stained new bone formation in the same sutures by histomorphometric analyses. The proposed studies are anticipated not only to determine the response characteristics of craniofacial bones to selected parameters of cyclic and static forces, but also to correlate mechanical stresses adjacent to craniofacial sutures with the amount of sutural bone resorption. In addition, the anticipated findings will form the basis of addressing the long-term goal of the present research to investigate the effects of a cascade of force parameters on inducing bone resorption in craniofacial bones.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
7R15DE013088-02
Application #
6231302
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1999-09-15
Project End
2002-09-14
Budget Start
2000-04-01
Budget End
2002-09-14
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Dentistry
Type
Schools of Dentistry
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Hong, L; Mao, J J (2004) Tissue-engineered rabbit cranial suture from autologous fibroblasts and BMP2. J Dent Res 83:751-6
Mao, Jeremy J; Nah, Hyun-Duck (2004) Growth and development: hereditary and mechanical modulations. Am J Orthod Dentofacial Orthop 125:676-89
Mao, Jeremy J; Wang, Xin; Mooney, Mark P et al. (2003) Strain induced osteogenesis of the craniofacial suture upon controlled delivery of low-frequency cyclic forces. Front Biosci 8:a10-7
Patel, Rupal V; Mao, Jeremy J (2003) Microstructural and elastic properties of the extracellular matrices of the superficial zone of neonatal articular cartilage by atomic force microscopy. Front Biosci 8:a18-25
Kopher, Ross A; Mao, Jeremy J (2003) Suture growth modulated by the oscillatory component of micromechanical strain. J Bone Miner Res 18:521-8
Kopher, Ross A; Nudera, James A; Wang, Xin et al. (2003) Expression of in vivo mechanical strain upon different wave forms of exogenous forces in rabbit craniofacial sutures. Ann Biomed Eng 31:1125-31
Hu, Kai; Qiguo, Rong; Fang, Jing et al. (2003) Effects of condylar fibrocartilage on the biomechanical loading of the human temporomandibular joint in a three-dimensional, nonlinear finite element model. Med Eng Phys 25:107-13
Mao, Jeremy J; Wang, Xin; Kopher, Ross A (2003) Biomechanics of craniofacial sutures: orthopedic implications. Angle Orthod 73:128-35
Wang, Xin; Mao, Jeremy J (2002) Accelerated chondrogenesis of the rabbit cranial base growth plate by oscillatory mechanical stimuli. J Bone Miner Res 17:1843-50
Wang, X; Mao, J J (2002) Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stresses. J Dent Res 81:701-5

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