Aerosol Infection Mouse Model for Cystic Fibrosis

Yu, Hongwei David

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Academic Research Enhancement Awards (AREA) (R15)
• Project #: 3R15DK058128-01A1S2
• Application #: 6752357
• Study Section: Lung Biology and Pathology Study Section (LBPA)
• Program Officer: Mckeon, Catherine T
• Project Start: 2002-04-01
• Project End: 2004-03-31
• Budget Start: 2003-04-01
• Budget End: 2004-03-31
• Support Year: 1
• Fiscal Year: 2003
• Total Cost: $24,434

Institution

• Name: Marshall University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 036156615
• City: Huntington
• State: WV
• Country: United States
• Zip Code: 25701

Publications

Poschet, Jens F; Timmins, Graham S; Taylor-Cousar, Jennifer L et al. (2007) Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 293:L712-9

Wilson, Kari R; Napper, Jennifer M; Denvir, James et al. (2007) Defect in early lung defence against Pseudomonas aeruginosa in DBA/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages. Microbiology 153:968-79

Head, Nathan E; Yu, Hongwei (2004) Cross-sectional analysis of clinical and environmental isolates of Pseudomonas aeruginosa: biofilm formation, virulence, and genome diversity. Infect Immun 72:133-44