): Under conditions of glaucoma, the cells of the retina begin to die, leading to progressive vision loss. This cell death may be due to a pressure-induced, excessive release of the neurotransmitter glutamate. While glutamate is a neurotransmitter normally used by retinal neurons, when it is present at high levels for a prolonged period of time, it is toxic to the cells, causing their death. The objectives of this study are to 1) Localize the source of excess glutamate, 2) Determine whether the amount of glutamate measured will lead to retinal cell death, and 3) Evaluate cannabinoids as possible drugs to prevent the retinal cell death.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
3R15EY012774-01A1S1
Application #
6650975
Study Section
Visual Sciences C Study Section (VISC)
Program Officer
Liberman, Ellen S
Project Start
2001-02-01
Project End
2005-01-31
Budget Start
2001-02-01
Budget End
2005-01-31
Support Year
1
Fiscal Year
2002
Total Cost
$104,862
Indirect Cost
Name
Westmont College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93108