Despite the potential importance of weight gain to smoking relapse, there has been virtually no success in eliminating, or even reducing, the weight gain following smoking cessation. Two promising pharmacologic methods for reducing postcessation weight gain are nicotine gum and an over-the-counter drug, phenylpropanolamine gum ([PPA]; Klesges et al., 1990). However, the relative efficacy of these two drugs has never been evaluated and the mechanisms of action of both drugs on weight gain are unknown. Given this introduction, we propose: (1) To determine the efficacy of nicotine gum and phenylpropanolamine (PPA) gum relative to a placebo in the reduction of postcessation weight gain throughout a 13-week combined behavioral and pharmacologic treatment program. Following cessation of the drugs at the end of treatment, we will monitor long-term effects of these drugs on body weight at both a 6- and a 12-month follow-up; (2) To determine the mechanism of action of both nicotine gum and PPA gum (viz., changes in dietary intake, physical activity, or metabolic rate) on change in weight during the course of treatment; (3) To evaluate withdrawal symptoms of smoking cessation as they are moderated by either nicotine gum or PPA gum use during the course of treatment; (4) To determine if PPA and nicotine gum produce an incremental effect on smoking cessation (relative to placebo gum) in a sample of female smokers who are at high risk for postcessation weight gain at posttest and at a 6- and 12-month follow-up.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Demonstration and Dissemination Projects (R18)
Project #
5R18HL045057-02
Application #
3442278
Study Section
Special Emphasis Panel (SRC (JR))
Project Start
1991-07-01
Project End
1996-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Memphis
Department
Type
Schools of Arts and Sciences
DUNS #
City
Memphis
State
TN
Country
United States
Zip Code
38152
Klesges, R C; Ward, K D; Ray, J W et al. (1998) The prospective relationships between smoking and weight in a young, biracial cohort: the Coronary Artery Risk Development in Young Adults Study. J Consult Clin Psychol 66:987-93
Ginsberg, J P; Klesges, R C; Johnson, K C et al. (1997) The relationship between a history of depression and adherence to a multicomponent smoking-cessation program. Addict Behav 22:783-7
Meyers, A W; Klesges, R C; Winders, S E et al. (1997) Are weight concerns predictive of smoking cessation? A prospective analysis. J Consult Clin Psychol 65:448-52
Eck, L H; Bennett, A G; Egan, B M et al. (1997) Differences in macronutrient selections in users and nonusers of an oral contraceptive. Am J Clin Nutr 65:419-24
Klesges, R C; Winders, S E; Meyers, A W et al. (1997) How much weight gain occurs following smoking cessation? A comparison of weight gain using both continuous and point prevalence abstinence. J Consult Clin Psychol 65:286-91
Rushing, P A; Winders, S E; Watson, S L et al. (1997) Acute administration of phenylpropanolamine fails to affect resting energy expenditure in men of normal weight. Obes Res 5:470-3
Klesges, R C; Klesges, L M; DeBon, M et al. (1995) Effects of phenylpropanolamine on withdrawal symptoms. Psychopharmacology (Berl) 119:85-91
Klesges, R C; Eck, L H; Ray, J W (1995) Who underreports dietary intake in a dietary recall? Evidence from the Second National Health and Nutrition Examination Survey. J Consult Clin Psychol 63:438-44
Audrain, J E; Klesges, R C; Klesges, L M (1995) Relationship between obesity and the metabolic effects of smoking in women. Health Psychol 14:116-23
Klesges, R C; Debon, M; Ray, J W (1995) Are self-reports of smoking rate biased? Evidence from the Second National Health and Nutrition Examination Survey. J Clin Epidemiol 48:1225-33

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