Advancing age is associated with a decline in functional status and an increase in the prevalence of chronic medical conditions. Disturbed nighttime sleep is also a common finding in older individuals. Epidemiologic data indicate that more than 50% of the adults over the age of 65 years have some form of a chronic sleep-related complaint. Numerous studies have documented that disruption of nocturnal sleep architecture is associated with daytime sleepiness and alterations in neuroendocrine function. Although studies with overnight polysomnography have examined the changes in sleep architecture with increasing age, the distinct effects of healthy aging and age-associated illnesses have not been rigorously investigated. The major objectives of this application are to describe the age-related changes in sleep architecture in the general population. Using the baseline polysomnographic data collected by the Sleep Heart Health Study, the current application will employ novel analytical techniques including multi-state survival analysis and spectral analysis to characterize the macro- and micro-alterations in sleep architecture across the age spectrum.
The Specific Aims of this application are as follows: (1) To characterize the independent effects of healthy aging on sleep micro-architecture in a community-based sample of middle-aged and older adults without medical co-morbidity; (2) To delineate the independent effects of sleep apnea on nocturnal sleep micro-architecture in middle-aged and older adults; and (3) To examine the combined effects of aging and sleep apnea on nocturnal sleep micro-architecture. The research proposed in this application will offer a unique perspective on sleep in the aging adult from the most extensive collection of polysomnographic data. Segregating the effects of normal aging from age-associated illness will identify potential sources of variability in sleep that occurs in older adults. Moreover, a comprehensive summary of the changes in sleep structure with increasing age will provide the necessary foundation for ongoing studies of aging cohorts to determine whether disruption of sleep architecture plays a significant role in the age-related predisposition to cardiovascular, metabolic, and neurobehavioral consequences. ? ?
| Pogach, Melanie S; Punjabi, Naresh M; Thomas, Neil et al. (2012) Electrocardiogram-based sleep spectrogram measures of sleep stability and glucose disposal in sleep disordered breathing. Sleep 35:139-48 |
| Di, Chong-Zhi; Crainiceanu, Ciprian M; Caffo, Brian S et al. (2009) MULTILEVEL FUNCTIONAL PRINCIPAL COMPONENT ANALYSIS. Ann Appl Stat 3:458-488 |
| Crainiceanu, Ciprian M; Caffo, Brian S; Di, Chong-Zhi et al. (2009) Nonparametric Signal Extraction and Measurement Error in the Analysis of Electroencephalographic Activity During Sleep. J Am Stat Assoc 104:541-555 |
| Stamatakis, Katherine; Sanders, Mark H; Caffo, Brian et al. (2008) Fasting glycemia in sleep disordered breathing: lowering the threshold on oxyhemoglobin desaturation. Sleep 31:1018-24 |
| Punjabi, Naresh M (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5:136-43 |
| Zhang, Lin; Samet, Jonathan; Caffo, Brian et al. (2008) Power spectral analysis of EEG activity during sleep in cigarette smokers. Chest 133:427-32 |
| Punjabi, Naresh M; Beamer, Brock A (2007) C-reactive protein is associated with sleep disordered breathing independent of adiposity. Sleep 30:29-34 |
| Stamatakis, Katherine A; Punjabi, Naresh M (2007) Long sleep duration: a risk to health or a marker of risk? Sleep Med Rev 11:337-9 |
| Punjabi, Naresh M; Beamer, Brock A; Jain, Alka et al. (2007) Elevated levels of neopterin in sleep-disordered breathing. Chest 132:1124-30 |
| Zhang, Lin; Samet, Jonathan; Caffo, Brian et al. (2006) Cigarette smoking and nocturnal sleep architecture. Am J Epidemiol 164:529-37 |
