Abstract

The goals of this proposal are to understand in more detail the trafficking of lymphocytes in HIV infection.
One aim focuses on patterns of lymph node (LN) involvement with HIV during the disease course using PET scanning to identify LN sites of activation (a presumed surrogate for sites of infection). This study will longitudinally follow newly infected and chronically subjects begun on HAART for about 18 mo and will translate to humans previous primate studies.
The second aim moves to the cellular level to study the chemotactic properties of CXCR4 and CCR5 tropic HIV gp120 or whole virions on different subsets of resting or activated T lymphocytes and monocytes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AI044725-02
Application #
2887946
Study Section
Special Emphasis Panel (ZRG5-AARR-2 (03))
Program Officer
Kagan, Jonathan M
Project Start
1998-09-30
Project End
2001-09-29
Budget Start
1999-09-30
Budget End
2001-09-29
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Iyengar, Sujatha; Chin, Bennett; Margolick, Joseph B et al. (2003) Anatomical loci of HIV-associated immune activation and association with viraemia. Lancet 362:945-50
Iyengar, S; Schwartz, D H; Clements, J E et al. (2000) CD4-independent, CCR5-dependent simian immunodeficiency virus infection and chemotaxis of human cells. J Virol 74:6720-4