The goal of this project is to characterize cellular immune responses to HIV-1 in highly exposed, uninfected (EU) individuals. As a """"""""naturally vaccinated"""""""" population these patients have been shown to mount HIV-1 specific CTL responses. The overall goal of this proposal is to characterize potential protective immune responses that could be targeted in an HIV-1 vaccine. This proposal aims to study 1) The clonality and persistence of CTL in EU women. These studies may provide insight into the mechanisms driving induction and maintenance of CTL in EU individuals. 2) Characterize the lymphocyte population including antigen specificity and cytokine release from cervicovaginal samples of EU women.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
7R21AI047746-02
Application #
6448794
Study Section
Special Emphasis Panel (ZRG1-VACC (03))
Program Officer
Bradac, James A
Project Start
2000-07-01
Project End
2002-06-30
Budget Start
2001-02-01
Budget End
2001-06-30
Support Year
2
Fiscal Year
2000
Total Cost
$143,790
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
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