Public Health Relevance

Vibrio cholerae has figured prominently in the history of infectious diseases as a cause of periodic global epidemics. Cholera still occurs widely. This study proposed will shed light on importance of V. cholerae?s virulence gene regulations in host-pathogen interactions, with the goal of better understanding V. cholerae pathogenesis and, potentially, discovering novel treatment options for the cholera disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AI088172-02
Application #
8135018
Study Section
Special Emphasis Panel (ZRG1-IDM-A (90))
Program Officer
Hall, Robert H
Project Start
2010-09-01
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2011
Total Cost
$197,532
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Rothenbacher, Francesca P; Zhu, Jun (2014) Efficient responses to host and bacterial signals during Vibrio cholerae colonization. Gut Microbes 5:120-8