The skin forms an essential barrier that protects us from the environment. The goals of this study are to determine the contribution of skin immune cells and their products in wound repair and innate immune defense against invading and/or transmitted microbes, including Zika virus. This work will contribute significantly to the development of novel approaches for treating skin wounds and infections. .
Human skin is a barrier organ and comprises an active immune system to provide host defense against otherwise deadly infections. This application will determine how IL-27 contributes to innate immune defense responses against virus infections, including Zika virus (ZIKV). ZIKV is transmitted primarily via the bite of a mosquito vector, which creates a wound in the skin. Our lab recently found that IL-27 is produced following cutaneous injury and initiates antiviral immune responses. In this application we plan to delineate IL-27's role in wound repair and the innate immune defense against virus infection.
| Handfield, Chelsea; Kwock, Jeffery; MacLeod, Amanda S (2018) Innate Antiviral Immunity in the Skin. Trends Immunol 39:328-340 |
| Smith, Jeffrey S; Nicholson, Lowell T; Suwanpradid, Jutamas et al. (2018) Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. Sci Signal 11: |
| Choi, Hae Woong; Suwanpradid, Jutamas; Kim, Il Hwan et al. (2018) Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science 362: |
| Smith, Jeffrey S; Suwanpradid, Jutamas; MacLeod, Amanda S et al. (2018) T Cells Expressing the Chemokine Receptor CXCR3 Localize to Positive Patch Test Reaction Sites. Dermatitis 29:228-229 |
