The degenerative disease of intervertebral disc (IVD) has a significant socio-economic impact. Despite the large amount of studies conducted in the field, the etiology of disc degeneration has not been fully delineated. The focus of this application is to develop realistic, finite element models for human intervertebral disc. To this end, we will first determine the constitutive relationship between human disc cell viability and it environment (Aim #1), and further develop and validate our model (Aim #2). This computational model, if successfully developed, can be used to simulate and analyze biological, chemical, electrical, and mechanical events in human discs under pathophysiological conditions, including cell activity and viability, extracellular glucose and oxygen concentrations, proteoglycan and water contents, pH, osmolarity, electrical potential and current, mechanical stresses and strains. The model can also be used to elucidate the mechanisms of disc degeneration in relation to mechanical loading and poor nutrition supply. The proposed studies will have significant impacts on understanding etiology of disc degeneration as well as on developing new strategy for tissue restoration or retardation of disc degeneration.

Public Health Relevance

The focus of this application is to develop a biophysics-based computer model for human intervertebral disc. The model can be used to systematically simulate and analyze biological, chemical, electrical, and mechanical signals within human intervertebral disc under pathophysiological conditions. The proposed studies will have significant impacts on understanding the etiology of disc degeneration as well as on developing new strategies for tissue restoration or retardation of disc degeneration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21AR066240-02
Application #
9115985
Study Section
Skeletal Biology Structure and Regeneration Study Section (SBSR)
Program Officer
Lester, Gayle E
Project Start
2015-07-25
Project End
2017-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Miami Coral Gables
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
625174149
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
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