Hepatosplenic T cell lymphoma is a rare, but lethal disease. The median age of onset is 35 and the expected median survival is less than two years. Very little is known about the genetic alterations underlying this disease. In this proposal we seek to define the genetics of the disease through exome and RNA sequencing of both primary human tumors and from the only known mouse model of the disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21CA195173-02
Application #
9036961
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Jhappan, Chamelli
Project Start
2015-04-01
Project End
2017-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
McKinney, Matthew; Moffitt, Andrea B; Gaulard, Philippe et al. (2017) The Genetic Basis of Hepatosplenic T-cell Lymphoma. Cancer Discov 7:369-379