This is an R21 application in response to RFA DA-02-001 entitled """"""""Neuroimaging Technology Development to Assess Brain and Behavior in Pediatric Populations"""""""". The proposal focuses on neuroimaging technology development in the context of examining maturation of reward and prediction circuitry. This frontostriatal circuitry is thought to be centrally involved in 1) addictive and impulsive behaviors relevant to substance abuse; and 2) repetitive or sequenced actions relevant to probabilistic and reward learning. We will examine the normal development of this circuitry and how it may be modified with experience using a converging methods approach. The Institute consists of faculty with expertise in the use of structural and functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), electroencephalographic (EEG) and evoked potential recording (ERP) techniques with typically and atypically developing children. The proposed studies involve the combined use of these technologies in both a hypothesis- and design-driven program of research. We will test specific hypotheses regarding the development and function of frontostriatat circuitry in the context of prediction and reward. Hypothesis testing will occur in the context of behavioral paradigm and design development for use with typically and ultimately atypically developing populations (e.g., substance abuse, prenatal exposure to substances). This work is innovative in that relatively little is known about the normal development of reward/prediction circuitry in humans. Understanding the normal development of this circuitry and how it may be modified with experience during sensitive periods of development is essential work that has direct implications for understanding basic mechanisms of substance abuse and maladaptive learning in children. The proposed studies will lay the critical groundwork, both scientific and methodological, for subsequent studies on substance abuse in children.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA015882-02
Application #
6664985
Study Section
Special Emphasis Panel (ZRG1-BDCN-5 (02))
Program Officer
Stanford, Laurence
Project Start
2002-09-30
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$166,720
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Karmiloff-Smith, Annette; Casey, B J; Massand, Esha et al. (2014) Environmental and Genetic Influences on Neurocognitive Development: The Importance of Multiple Methodologies and Time-Dependent Intervention. Clin Psychol Sci 2:628-637
Spicer, Julie; Galvan, Adriana; Hare, Todd A et al. (2007) Sensitivity of the nucleus accumbens to violations in expectation of reward. Neuroimage 34:455-61
Galvan, Adriana; Hare, Todd; Voss, Henning et al. (2007) Risk-taking and the adolescent brain: who is at risk? Dev Sci 10:F8-F14
Liston, Conor; Matalon, Shanna; Hare, Todd A et al. (2006) Anterior cingulate and posterior parietal cortices are sensitive to dissociable forms of conflict in a task-switching paradigm. Neuron 50:643-53
Liston, Conor; Watts, Richard; Tottenham, Nim et al. (2006) Frontostriatal microstructure modulates efficient recruitment of cognitive control. Cereb Cortex 16:553-60
Durston, Sarah; Davidson, Matthew C; Tottenham, Nim et al. (2006) A shift from diffuse to focal cortical activity with development. Dev Sci 9:1-8
Durston, Sarah; Casey, B J (2006) What have we learned about cognitive development from neuroimaging? Neuropsychologia 44:2149-57
Eigsti, Inge-Marie; Zayas, Vivian; Mischel, Walter et al. (2006) Predicting cognitive control from preschool to late adolescence and young adulthood. Psychol Sci 17:478-84
Kotsoni, Eleni; Byrd, Dana; Casey, B J (2006) Special considerations for functional magnetic resonance imaging of pediatric populations. J Magn Reson Imaging 23:877-86
Scerif, Gaia; Worden, Michael S; Davidson, Matthew et al. (2006) Context modulates early stimulus processing when resolving stimulus-response conflict. J Cogn Neurosci 18:781-92

Showing the most recent 10 out of 20 publications