Marijuana dependence is a significant problem in the United States today. It is critical to expand the investigation of treatment options for patients with marijuana use disorders. Attention deficit hyperactivity disorder (ADHD) commonly co-occurs in patients with marijuana use disorders, and comorbid substance use disorders have been shown to worsen treatment outcomes. Dopamine dysfunction is a hypothesized link between ADHD and substance use disorders, and it has been postulated that illicit substances may be used by individuals with ADHD to overcome a relative lack of dopamine transmission. Preliminary studies suggest that the use of medications that increase dopaminergic levels may improve substance use outcomes in these patients. The first-line treatment of ADHD is stimulant medications. However, there has been concern about the use of stimulants in individuals with substance use disorders because of the abuse potential of these agents. This R21 application proposes to explore the treatment of adult patients with comorbid marijuana dependence and ADHD with atomoxetine, a recently approved non-stimulant ADHD medication. Subjects will receive treatment with either atomoxetine or placebo for 12 weeks combined with brief motivational enhancement therapy. Measures of marijuana use and craving and ADHD symptomatology will be collected.
The specific aims of this project are to gather preliminary data on the safety and efficacy of atomoxetine in reducing marijuana use in adult patients with comorbid ADHD and marijuana dependence, and to preliminarily evaluate the efficacy of atomoxetine in reducing ADHD symptoms in this population. The proposed work is novel in that little clinical research has focused on marijuana-dependent patients with ADHD, and no work has been published examining the safety, tolerability, or efficacy of atomoxetine inpatients with this comorbidity. The project is designed to increase our knowledge of treatment options for patients with marijuana dependence, an area which has been under investigated. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA018221-02
Application #
7140418
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Montoya, Ivan
Project Start
2005-07-20
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2009-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$169,313
Indirect Cost
Name
Medical University of South Carolina
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
McRae-Clark, Aimee L; Carter, Rickey E; Killeen, Therese K et al. (2010) A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder. Am J Addict 19:481-9