The investigators propose to study a group of approximately 35 patients with tinnitus resulting from various etiologies using psychophysical measures to ascertain the pitch, intensity, and masking susceptibility of each subject's tinnitus. Functional activation images of cortical and subcortical areas will be obtained by comparing MR images acquired while patients are experiencing tinnitus with images acquired while the tinnitus is masked or modified by presentation of broadband noise. MR activity in tinnitus patients will be compared with that of normal subjects and hearing-impaired patients stimulated with broadband noise.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21DC003255-01
Application #
2014823
Study Section
Special Emphasis Panel (ZDC1-SRB-S (03))
Project Start
1997-01-01
Project End
1998-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Melcher, J R; Sigalovsky, I S; Guinan Jr, J J et al. (2000) Lateralized tinnitus studied with functional magnetic resonance imaging: abnormal inferior colliculus activation. J Neurophysiol 83:1058-72
Levine, R A (1999) Somatic (craniocervical) tinnitus and the dorsal cochlear nucleus hypothesis. Am J Otolaryngol 20:351-62